Skeletal muscle aging and the mitochondrion

Matthew L. Johnson, Matthew M. Robinson, Sreekumaran K. Nair

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations

Abstract

Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging process. A growing body of research in the areas of bioenergetics and protein turnover has placed the mitochondria at the center of this process. It is now clear that, unless an active lifestyle is rigorously followed, skeletal muscle mitochondrial decline occurs as humans age. Increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, many of which are potential therapeutic targets, and highlight the beneficial effects of vigorous physical activity on skeletal muscle health for an aging population.

Original languageEnglish (US)
Pages (from-to)247-256
Number of pages10
JournalTrends in Endocrinology and Metabolism
Volume24
Issue number5
DOIs
StatePublished - May 2013

Keywords

  • Aging
  • Mitochondria
  • Protein metabolism
  • Protein synthesis
  • Sarcopenia

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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