Abstract
A number of PET agents are useful for evaluation of skeletal metastatic disease, and have significant advantages over 99mTc-MDP scintigraphy, including superior diagnostic accuracy, higher spatial resolution, and shorter imaging times- often with the ability to depict soft tissue local recurrence and metastasis in the same examination. While these agents have excellent diagnostic utility, they are not 100% specific for skeletal metastasis, and so normal patterns of biodistribution, benign osseous lesions that may demonstrate radiotracer uptake, and the significance of morphologic changes on CT such as osteolysis or osteosclerosis must be kept in mind to ensure accurate interpretation.
| Language | English (US) |
|---|---|
| Pages | 103-120 |
| Number of pages | 18 |
| Journal | PET Clinics |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Choline
- FDG
- Fluciclovine
- NaF
- PET/CT
- Skeletal metastasis
ASJC Scopus subject areas
- Radiation
- Radiology Nuclear Medicine and imaging
Cite this
Skeletal Metastasis Evaluation : Value and Impact of PET/Computed Tomography on Diagnosis, Management and Prognosis. / Broski, Stephen; Young, Jason R.; Kendi, Ayse T.; Subramaniam, Rathan M.
In: PET Clinics, Vol. 14, No. 1, 01.01.2019, p. 103-120.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Skeletal Metastasis Evaluation
T2 - PET Clinics
AU - Broski, Stephen
AU - Young, Jason R.
AU - Kendi, Ayse T.
AU - Subramaniam, Rathan M.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - A number of PET agents are useful for evaluation of skeletal metastatic disease, and have significant advantages over 99mTc-MDP scintigraphy, including superior diagnostic accuracy, higher spatial resolution, and shorter imaging times- often with the ability to depict soft tissue local recurrence and metastasis in the same examination. While these agents have excellent diagnostic utility, they are not 100% specific for skeletal metastasis, and so normal patterns of biodistribution, benign osseous lesions that may demonstrate radiotracer uptake, and the significance of morphologic changes on CT such as osteolysis or osteosclerosis must be kept in mind to ensure accurate interpretation.
AB - A number of PET agents are useful for evaluation of skeletal metastatic disease, and have significant advantages over 99mTc-MDP scintigraphy, including superior diagnostic accuracy, higher spatial resolution, and shorter imaging times- often with the ability to depict soft tissue local recurrence and metastasis in the same examination. While these agents have excellent diagnostic utility, they are not 100% specific for skeletal metastasis, and so normal patterns of biodistribution, benign osseous lesions that may demonstrate radiotracer uptake, and the significance of morphologic changes on CT such as osteolysis or osteosclerosis must be kept in mind to ensure accurate interpretation.
KW - Choline
KW - FDG
KW - Fluciclovine
KW - NaF
KW - PET/CT
KW - Skeletal metastasis
UR - http://www.scopus.com/inward/record.url?scp=85055266371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055266371&partnerID=8YFLogxK
U2 - 10.1016/j.cpet.2018.08.006
DO - 10.1016/j.cpet.2018.08.006
M3 - Review article
VL - 14
SP - 103
EP - 120
JO - PET Clinics
JF - PET Clinics
SN - 1556-8598
IS - 1
ER -