TY - JOUR
T1 - Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia
AU - Stirewalt, Derek L.
AU - Kopecky, Kenneth J.
AU - Meshinchi, Soheil
AU - Engel, Julia H.
AU - Pogosova-Agadjanyan, Era L.
AU - Linsley, Jeremy
AU - Slovak, Marilyn L.
AU - Willman, Cheryl L.
AU - Radich, Jerald P.
PY - 2006/5/1
Y1 - 2006/5/1
N2 - FLT3 internal tandem duplications (FLT3/ITDs) in the juxtamembrane domain are found in approximately 25% of acute myeloid leukemia (AML) patients, ranging in size from 3 to hundreds of nucleotides. We examined whether the sizes of FLT3/ITDs were associated with clinical outcomes in 151 AML patients enrolled in Southwest Oncology Group studies: S9333 and S9500. FLT3/ITDs were identified in 32% of patients (median ITD size = 39 nucleotides; range, 15-153 nucleotides). The CR rates were 35%, 67%, and 52% for patients with large (≥ 40), small (< 40), and no ITDs, respectively (P = .19). Increasing ITD size was associated with decreasing OS (estimated 5-year OS: large = 13%, small = 26%, and no ITD = 21%, P = .072) and RFS (estimated 5-year RFS: large = 13%, small = 27%, and no ITD = 34%, P = .017). These studies suggest that ITD size may have prognostic significance.
AB - FLT3 internal tandem duplications (FLT3/ITDs) in the juxtamembrane domain are found in approximately 25% of acute myeloid leukemia (AML) patients, ranging in size from 3 to hundreds of nucleotides. We examined whether the sizes of FLT3/ITDs were associated with clinical outcomes in 151 AML patients enrolled in Southwest Oncology Group studies: S9333 and S9500. FLT3/ITDs were identified in 32% of patients (median ITD size = 39 nucleotides; range, 15-153 nucleotides). The CR rates were 35%, 67%, and 52% for patients with large (≥ 40), small (< 40), and no ITDs, respectively (P = .19). Increasing ITD size was associated with decreasing OS (estimated 5-year OS: large = 13%, small = 26%, and no ITD = 21%, P = .072) and RFS (estimated 5-year RFS: large = 13%, small = 27%, and no ITD = 34%, P = .017). These studies suggest that ITD size may have prognostic significance.
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U2 - 10.1182/blood-2005-08-3453
DO - 10.1182/blood-2005-08-3453
M3 - Article
C2 - 16368883
AN - SCOPUS:33646431111
SN - 0006-4971
VL - 107
SP - 3724
EP - 3726
JO - Blood
JF - Blood
IS - 9
ER -