Sipuleucel-T for therapy of asymptomatic or minimally symptomatic, castrate-refractory prostate cancer: An update and perspective among other treatments

Shilpa Gupta, Estrella Carballido, Mayer Fishman

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Sipuleucel-T is an autologous cell immunotherapy for castrate-refractory prostate cancer, with US Food and Drug Administration (FDA) approval in asymptomatic or minimally symptomatic prostate cancer. In this review we address the background of prostate cancer incidence and other available therapy onto which sipuleucel-T treatment has been added, with discussion of hormone-therapy, chemotherapy, and other investigational immunotherapies. The sipuleucel-T manufacturing process, toxicity and clinical benefit are reviewed, along with an examination of the issue of clinical benefit to survival, independent of apparent changes of prostate-specific antigen (PSA) levels. Sipuleucel-T therapy is appraised from clinician, patient and immunotherapeutic perspectives, with reference to the clinical data from the pivotal trial, the mechanism of action, and the treatment process.

Original languageEnglish (US)
Pages (from-to)79-96
Number of pages18
JournalOncoTargets and Therapy
Volume4
DOIs
StatePublished - 2011

Keywords

  • Dendritic cells
  • Immunotherapy
  • Sipuleucel-T
  • Vaccine

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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