TY - JOUR
T1 - Sinonasal Schneiderian papillomas
T2 - human papillomavirus typing by polymerase chain reaction.
AU - Sarkar, F. H.
AU - Visscher, D. W.
AU - Kintanar, E. B.
AU - Zarbo, R. J.
AU - Crissman, J. D.
PY - 1992/5
Y1 - 1992/5
N2 - A series of 35 formalin-fixed, paraffin-embedded Schneiderian papillomas (24 inverted, nine cylindrical cell type, and two fungiform) of the nasal cavity were evaluated for the presence of human papillomavirus (HPV) types 6b/11, 16, and 18 DNA sequences using both a highly sensitive and specific modification of the polymerase chain reaction technique and conventional in situ hybridization. The HPV gene sequences (E6-E7 portions) were not detected in any of the 24 inverted or nine cylindrical cell papillomas. One of the fungiform papillomas was positive for HPV 6b/11. We conclude: (a) the origin of most Schneiderian sinonasal papillomas is not associated with HPV infection of these common types, and (b) fungiform papilloma is a distinctive clinicopathologic subtype of Schneiderian papilloma that may be HPV-related.
AB - A series of 35 formalin-fixed, paraffin-embedded Schneiderian papillomas (24 inverted, nine cylindrical cell type, and two fungiform) of the nasal cavity were evaluated for the presence of human papillomavirus (HPV) types 6b/11, 16, and 18 DNA sequences using both a highly sensitive and specific modification of the polymerase chain reaction technique and conventional in situ hybridization. The HPV gene sequences (E6-E7 portions) were not detected in any of the 24 inverted or nine cylindrical cell papillomas. One of the fungiform papillomas was positive for HPV 6b/11. We conclude: (a) the origin of most Schneiderian sinonasal papillomas is not associated with HPV infection of these common types, and (b) fungiform papilloma is a distinctive clinicopathologic subtype of Schneiderian papilloma that may be HPV-related.
UR - http://www.scopus.com/inward/record.url?scp=0026856018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026856018&partnerID=8YFLogxK
M3 - Article
C2 - 1323107
AN - SCOPUS:0026856018
SN - 0893-3952
VL - 5
SP - 329
EP - 332
JO - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
IS - 3
ER -