Single proteins might have dual but related functions in intracellular and extracellular microenvironments

Derek C. Radisky, Melody Stallings-Mann, Yohei Hirai, Mina J. Bissell

Research output: Contribution to journalReview article

72 Scopus citations

Abstract

The maintenance of organ homeostasis and the control of an appropriate response to environmental alterations require the intimate coordination of cellular functions and tissue organization. An important component of this coordination could be provided by proteins that can have distinct but linked functions on both sides of the plasma membrane. We present a model that proposes that unconventional secretion provides a mechanism through which single proteins can integrate complex tissue functions.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalNature Reviews Molecular Cell Biology
Volume10
Issue number3
DOIs
StatePublished - Mar 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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