Single lead ST-segment recovery: A simple, reliable measure of successful fibrinolysis after acute myocardial infarction

Mushabbar A. Syed, Steven Borzak, Abed Asfour, Madhavi Gunda, Omar Obeidat, Sabina A. Murphy, Raymond J Gibbons, Steven G. Gourlay, Hal V. Barron, W. Douglas Weaver, Michael Hudson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Successful reperfusion after acute ST-elevation myocardial infarction improves prognosis. Among the different electrocardiographic markers of reperfusion, sum ST resolution is considered the hallmark of reperfusion, but is cumbersome to use. Methods: To assess the usefulness of a single lead ST resolution at 90 minutes after fibrinolysis compared with the sum ST resolution in predicting Thrombolysis in Myocardial Infarction (TIMI) grade 3 flow, we used prospectively collected data from the Limitation of Myocardial Injury Following Thrombolysis in Acute Myocardial Infarction (LIMIT-AMI) study. All patients had electrocardiograms recorded at presentation and 90 minutes and a coronary angiogram 90 minutes after fibrinolysis. Results: Infarction artery patency was assessed in 238 patients with 4 different ST resolution criteria: single lead ST resolution ≥50% and ≥70% and sum ST resolution ≥50% and ≥70%. The most sensitive criteria for TIMI grade 3 flow was single lead ST resolution ≥50% (sensitivity rate, 70%; specificity rate, 54%), whereas sum ST resolution ≥70% was most the specific criteria (sensitivity rate, 45%; specificity rate, 79%). The proportion of patients with TIMI grade 3 flow was similar in all 4 ST resolution groups (P = .84). Pre-discharge infarction size and ejection fraction were also similar. No single lead or sum lead measure of ST resolution was significantly associated with an increased risk of death, heart failure, or reinfarction. Conclusion: We propose that single lead ST-resolution ≥50% as an optimal electrocardiographic indicator for successful reperfusion 90 minutes after fibrinolysis. This simple electrocardiographic measure should be combined with bedside clinical and hemodynamic assessment to optimize decision making after fibrinolysis.

Original languageEnglish (US)
Pages (from-to)275-280
Number of pages6
JournalAmerican Heart Journal
Volume147
Issue number2
DOIs
StatePublished - Feb 2004

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Fibrinolysis
Myocardial Infarction
Reperfusion
Infarction
Decision Making
Angiography
Electrocardiography
Heart Failure
Arteries
Hemodynamics
Lead
Wounds and Injuries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Single lead ST-segment recovery : A simple, reliable measure of successful fibrinolysis after acute myocardial infarction. / Syed, Mushabbar A.; Borzak, Steven; Asfour, Abed; Gunda, Madhavi; Obeidat, Omar; Murphy, Sabina A.; Gibbons, Raymond J; Gourlay, Steven G.; Barron, Hal V.; Weaver, W. Douglas; Hudson, Michael.

In: American Heart Journal, Vol. 147, No. 2, 02.2004, p. 275-280.

Research output: Contribution to journalArticle

Syed, MA, Borzak, S, Asfour, A, Gunda, M, Obeidat, O, Murphy, SA, Gibbons, RJ, Gourlay, SG, Barron, HV, Weaver, WD & Hudson, M 2004, 'Single lead ST-segment recovery: A simple, reliable measure of successful fibrinolysis after acute myocardial infarction', American Heart Journal, vol. 147, no. 2, pp. 275-280. https://doi.org/10.1016/j.ahj.2003.08.010
Syed, Mushabbar A. ; Borzak, Steven ; Asfour, Abed ; Gunda, Madhavi ; Obeidat, Omar ; Murphy, Sabina A. ; Gibbons, Raymond J ; Gourlay, Steven G. ; Barron, Hal V. ; Weaver, W. Douglas ; Hudson, Michael. / Single lead ST-segment recovery : A simple, reliable measure of successful fibrinolysis after acute myocardial infarction. In: American Heart Journal. 2004 ; Vol. 147, No. 2. pp. 275-280.
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abstract = "Background: Successful reperfusion after acute ST-elevation myocardial infarction improves prognosis. Among the different electrocardiographic markers of reperfusion, sum ST resolution is considered the hallmark of reperfusion, but is cumbersome to use. Methods: To assess the usefulness of a single lead ST resolution at 90 minutes after fibrinolysis compared with the sum ST resolution in predicting Thrombolysis in Myocardial Infarction (TIMI) grade 3 flow, we used prospectively collected data from the Limitation of Myocardial Injury Following Thrombolysis in Acute Myocardial Infarction (LIMIT-AMI) study. All patients had electrocardiograms recorded at presentation and 90 minutes and a coronary angiogram 90 minutes after fibrinolysis. Results: Infarction artery patency was assessed in 238 patients with 4 different ST resolution criteria: single lead ST resolution ≥50{\%} and ≥70{\%} and sum ST resolution ≥50{\%} and ≥70{\%}. The most sensitive criteria for TIMI grade 3 flow was single lead ST resolution ≥50{\%} (sensitivity rate, 70{\%}; specificity rate, 54{\%}), whereas sum ST resolution ≥70{\%} was most the specific criteria (sensitivity rate, 45{\%}; specificity rate, 79{\%}). The proportion of patients with TIMI grade 3 flow was similar in all 4 ST resolution groups (P = .84). Pre-discharge infarction size and ejection fraction were also similar. No single lead or sum lead measure of ST resolution was significantly associated with an increased risk of death, heart failure, or reinfarction. Conclusion: We propose that single lead ST-resolution ≥50{\%} as an optimal electrocardiographic indicator for successful reperfusion 90 minutes after fibrinolysis. This simple electrocardiographic measure should be combined with bedside clinical and hemodynamic assessment to optimize decision making after fibrinolysis.",
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AU - Asfour, Abed

AU - Gunda, Madhavi

AU - Obeidat, Omar

AU - Murphy, Sabina A.

AU - Gibbons, Raymond J

AU - Gourlay, Steven G.

AU - Barron, Hal V.

AU - Weaver, W. Douglas

AU - Hudson, Michael

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N2 - Background: Successful reperfusion after acute ST-elevation myocardial infarction improves prognosis. Among the different electrocardiographic markers of reperfusion, sum ST resolution is considered the hallmark of reperfusion, but is cumbersome to use. Methods: To assess the usefulness of a single lead ST resolution at 90 minutes after fibrinolysis compared with the sum ST resolution in predicting Thrombolysis in Myocardial Infarction (TIMI) grade 3 flow, we used prospectively collected data from the Limitation of Myocardial Injury Following Thrombolysis in Acute Myocardial Infarction (LIMIT-AMI) study. All patients had electrocardiograms recorded at presentation and 90 minutes and a coronary angiogram 90 minutes after fibrinolysis. Results: Infarction artery patency was assessed in 238 patients with 4 different ST resolution criteria: single lead ST resolution ≥50% and ≥70% and sum ST resolution ≥50% and ≥70%. The most sensitive criteria for TIMI grade 3 flow was single lead ST resolution ≥50% (sensitivity rate, 70%; specificity rate, 54%), whereas sum ST resolution ≥70% was most the specific criteria (sensitivity rate, 45%; specificity rate, 79%). The proportion of patients with TIMI grade 3 flow was similar in all 4 ST resolution groups (P = .84). Pre-discharge infarction size and ejection fraction were also similar. No single lead or sum lead measure of ST resolution was significantly associated with an increased risk of death, heart failure, or reinfarction. Conclusion: We propose that single lead ST-resolution ≥50% as an optimal electrocardiographic indicator for successful reperfusion 90 minutes after fibrinolysis. This simple electrocardiographic measure should be combined with bedside clinical and hemodynamic assessment to optimize decision making after fibrinolysis.

AB - Background: Successful reperfusion after acute ST-elevation myocardial infarction improves prognosis. Among the different electrocardiographic markers of reperfusion, sum ST resolution is considered the hallmark of reperfusion, but is cumbersome to use. Methods: To assess the usefulness of a single lead ST resolution at 90 minutes after fibrinolysis compared with the sum ST resolution in predicting Thrombolysis in Myocardial Infarction (TIMI) grade 3 flow, we used prospectively collected data from the Limitation of Myocardial Injury Following Thrombolysis in Acute Myocardial Infarction (LIMIT-AMI) study. All patients had electrocardiograms recorded at presentation and 90 minutes and a coronary angiogram 90 minutes after fibrinolysis. Results: Infarction artery patency was assessed in 238 patients with 4 different ST resolution criteria: single lead ST resolution ≥50% and ≥70% and sum ST resolution ≥50% and ≥70%. The most sensitive criteria for TIMI grade 3 flow was single lead ST resolution ≥50% (sensitivity rate, 70%; specificity rate, 54%), whereas sum ST resolution ≥70% was most the specific criteria (sensitivity rate, 45%; specificity rate, 79%). The proportion of patients with TIMI grade 3 flow was similar in all 4 ST resolution groups (P = .84). Pre-discharge infarction size and ejection fraction were also similar. No single lead or sum lead measure of ST resolution was significantly associated with an increased risk of death, heart failure, or reinfarction. Conclusion: We propose that single lead ST-resolution ≥50% as an optimal electrocardiographic indicator for successful reperfusion 90 minutes after fibrinolysis. This simple electrocardiographic measure should be combined with bedside clinical and hemodynamic assessment to optimize decision making after fibrinolysis.

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