Single-dose pharmacokinetics of the DNA-binding bioreductive agent NLCQ-1 (NSC 709257) in CD2F₁ mice

Medicine & Life Sciences

• 4-(3-(2-nitro-1-imidazolyl)-propylamino)-7-chloroquinoline hydrochloride 100%
• Pharmacokinetics 35%
• DNA 26%
• Rodentia 8%
• quinoline 7%
• Calibration 5%
• Serum Albumin 5%
• Tumor Cell Line 5%
• Protein Binding 5%
• Intravenous Administration 4%
• Biological Availability 4%
• Heterografts 4%
• Blood Proteins 4%
• Oral Administration 4%
• Glycoproteins 4%
• High Pressure Liquid Chromatography 4%
• Acids 3%
• Dogs 3%
• Urine 3%
• Radiotherapy 3%
• Drug Therapy 3%
• In Vitro Techniques 2%
• Neoplasms 1%

Chemical Compounds

• Pharmacokinetics 35%
• Plasma 28%
• Antiproliferative 18%
• Dose 14%
• Intraperitoneal 11%
• Plasma Concentration 10%
• Quinoline 9%
• Bioavailability 9%
• Antitumor 8%
• Glycoprotein 8%
• Analytical Calibration 8%
• Organic Solvent 6%
• Protein 3%