Single dose kinetics of rifampicin and isoniazid in well-nourished and malnourished patients of tuberculosis

S. K. Garg, R. Dhand, S. K. Malik, Sanjay Kalra, P. H. Gupta, V. K. Jha, V. K. Shukla, R. Lal

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A single dose kinetics of isoniazid and rifampicin alone, and combination was studied in well-nourished and malnourished patients of tuberculosis. The elimination half-life of isoniazid was significantly increased when administered in combination with rifampicin in well-nourished and malnourished patients, while no significant difference was observed in any of the pharmacokinetic parameters of rifampicin in combination with isoniazid or alone in both groups of patients. Results are discussed on the basis of pharmacokinetic drug interaction.

Original languageEnglish (US)
Pages (from-to)417-420
Number of pages4
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Volume26
Issue number8
StatePublished - Jan 1 1988
Externally publishedYes

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Isoniazid
Rifampin
Tuberculosis
Pharmacokinetics
Kinetics
Drug interactions
Drug Interactions
Half-Life

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

Single dose kinetics of rifampicin and isoniazid in well-nourished and malnourished patients of tuberculosis. / Garg, S. K.; Dhand, R.; Malik, S. K.; Kalra, Sanjay; Gupta, P. H.; Jha, V. K.; Shukla, V. K.; Lal, R.

In: International Journal of Clinical Pharmacology Therapy and Toxicology, Vol. 26, No. 8, 01.01.1988, p. 417-420.

Research output: Contribution to journalArticle

Garg, S. K. ; Dhand, R. ; Malik, S. K. ; Kalra, Sanjay ; Gupta, P. H. ; Jha, V. K. ; Shukla, V. K. ; Lal, R. / Single dose kinetics of rifampicin and isoniazid in well-nourished and malnourished patients of tuberculosis. In: International Journal of Clinical Pharmacology Therapy and Toxicology. 1988 ; Vol. 26, No. 8. pp. 417-420.
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