TY - JOUR
T1 - Simultaneous kidney transplantation and bilateral native nephrectomy for polycystic kidney disease
AU - Tyson, Mark D.
AU - Wisenbaugh, Eric S.
AU - Andrews, Paul E.
AU - Castle, Erik P.
AU - Humphreys, Mitchell R.
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2013/12
Y1 - 2013/12
N2 - Purpose: Bilateral native nephrectomy with simultaneous kidney transplantation is becoming more common for patients with polycystic kidney disease in the living donor nephrectomy era. Single center reports evaluating the short-term and longterm outcomes of simultaneous kidney transplantation have been published but are generally limited by small sample sizes. We examined population level data to broadly define the complications of simultaneous kidney transplantation. Materials and Methods: The Nationwide Inpatient Sample (NIS) was used to acquire data on 2,368 patients with polycystic kidney disease treated with bilateral native nephrectomy between 1998 and 2010. We performed unadjusted, multivariable and propensity score adjusted analyses of postoperative outcomes. Results: A total of 2,368 patients were included in this study. The 271 patients (11.4%) who underwent simultaneous kidney transplantation had higher rates of intraoperative hemorrhage, blood transfusion and urological complications (propensity score adjusted OR 3.3, p = 0.01, OR 4.2, p <0.0001 and OR 5.5, p <0.0001, respectively) but a lower in-hospital mortality rate (15.8% vs 1.1%, propensity score adjusted OR 0.10, p <0.0001). Median hospitalization was also significantly higher in patients who underwent simultaneous kidney transplantation (6 vs 9 days, p <0.0001). For the top quartile of high volume hospitals the rates of intraoperative hemorrhage, blood transfusion and urological complications remained statistically higher in patients treated with simultaneous kidney transplantation but in-hospital mortality was similar on multivariable logistic regression (OR 0.2, p = 0.17). Conclusions: Except for increased rates of intraoperative hemorrhage, blood transfusion and urological complications there were no significant differences in postoperative adverse outcomes in this large, population based study of patients who underwent simultaneous kidney transplantation compared to bilateral native nephrectomy alone.
AB - Purpose: Bilateral native nephrectomy with simultaneous kidney transplantation is becoming more common for patients with polycystic kidney disease in the living donor nephrectomy era. Single center reports evaluating the short-term and longterm outcomes of simultaneous kidney transplantation have been published but are generally limited by small sample sizes. We examined population level data to broadly define the complications of simultaneous kidney transplantation. Materials and Methods: The Nationwide Inpatient Sample (NIS) was used to acquire data on 2,368 patients with polycystic kidney disease treated with bilateral native nephrectomy between 1998 and 2010. We performed unadjusted, multivariable and propensity score adjusted analyses of postoperative outcomes. Results: A total of 2,368 patients were included in this study. The 271 patients (11.4%) who underwent simultaneous kidney transplantation had higher rates of intraoperative hemorrhage, blood transfusion and urological complications (propensity score adjusted OR 3.3, p = 0.01, OR 4.2, p <0.0001 and OR 5.5, p <0.0001, respectively) but a lower in-hospital mortality rate (15.8% vs 1.1%, propensity score adjusted OR 0.10, p <0.0001). Median hospitalization was also significantly higher in patients who underwent simultaneous kidney transplantation (6 vs 9 days, p <0.0001). For the top quartile of high volume hospitals the rates of intraoperative hemorrhage, blood transfusion and urological complications remained statistically higher in patients treated with simultaneous kidney transplantation but in-hospital mortality was similar on multivariable logistic regression (OR 0.2, p = 0.17). Conclusions: Except for increased rates of intraoperative hemorrhage, blood transfusion and urological complications there were no significant differences in postoperative adverse outcomes in this large, population based study of patients who underwent simultaneous kidney transplantation compared to bilateral native nephrectomy alone.
KW - Kidney
KW - Kidney transplantation
KW - Nephrectomy
KW - Outcome assessment (health care)
KW - Polycystic kidney diseases
UR - http://www.scopus.com/inward/record.url?scp=84888638610&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888638610&partnerID=8YFLogxK
U2 - 10.1016/j.juro.2013.05.057
DO - 10.1016/j.juro.2013.05.057
M3 - Article
C2 - 23727414
AN - SCOPUS:84888638610
SN - 0022-5347
VL - 190
SP - 2170
EP - 2174
JO - Journal of Urology
JF - Journal of Urology
IS - 6
ER -