Simultaneous kidney-pancreas transplantation in a patient with small lymphocytic lymphoma

Ramon A.L. Romero; K. Sudhakar Reddy; Thomas D. Johnston; Thomas W. Waid; J. Wade MeKeown; Taqi Khan; Dennis Karounos; Michael Doukas; Luis Samayoa; Dinesh Ranjan

doi:10.1097/01.TP.0000047309.31708.CD

Simultaneous kidney-pancreas transplantation in a patient with small lymphocytic lymphoma

Ramon A.L. Romero, K. Sudhakar Reddy, Thomas D. Johnston, Thomas W. Waid, J. Wade MeKeown, Taqi Khan, Dennis Karounos, Michael Doukas, Luis Samayoa, Dinesh Ranjan

Diagnostic Radiology

Research output: Contribution to journal › Article › peer-review

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Abstract

Background. Experience with organ transplantation in patients with indolent lymphoma is limited, and it is unknown how the natural history of the disease is altered by chronic immunosuppressive therapy. Methods. A patient with type 1 diabetes and renal failure who underwent simultaneous kidney-pancreas transplantation was found to have stage IV small lymphocytic lymphoma at the time of transplantation. He received quadruple immunosuppressive therapy using interleukin (IL)-2 receptor antibody, tacrolimus, mycophenolate mofetil, and prednisone. Results. Patient is doing well 3 years posttransplant with excellent graft function of both the kidney and pancreas without any evidence of progression of the disease. Conclusion. Indolent lymphoma should not be considered an absolute contraindication to organ transplantation.

Original language	English (US)
Pages (from-to)	414-416
Number of pages	3
Journal	Transplantation
Volume	75
Issue number	3
DOIs	https://doi.org/10.1097/01.TP.0000047309.31708.CD
State	Published - Feb 15 2003

ASJC Scopus subject areas

Transplantation

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10.1097/01.TP.0000047309.31708.CD

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title = "Simultaneous kidney-pancreas transplantation in a patient with small lymphocytic lymphoma",

abstract = "Background. Experience with organ transplantation in patients with indolent lymphoma is limited, and it is unknown how the natural history of the disease is altered by chronic immunosuppressive therapy. Methods. A patient with type 1 diabetes and renal failure who underwent simultaneous kidney-pancreas transplantation was found to have stage IV small lymphocytic lymphoma at the time of transplantation. He received quadruple immunosuppressive therapy using interleukin (IL)-2 receptor antibody, tacrolimus, mycophenolate mofetil, and prednisone. Results. Patient is doing well 3 years posttransplant with excellent graft function of both the kidney and pancreas without any evidence of progression of the disease. Conclusion. Indolent lymphoma should not be considered an absolute contraindication to organ transplantation.",

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T1 - Simultaneous kidney-pancreas transplantation in a patient with small lymphocytic lymphoma

AU - Romero, Ramon A.L.

AU - Reddy, K. Sudhakar

AU - Johnston, Thomas D.

AU - Waid, Thomas W.

AU - MeKeown, J. Wade

AU - Khan, Taqi

AU - Karounos, Dennis

AU - Doukas, Michael

AU - Samayoa, Luis

AU - Ranjan, Dinesh

PY - 2003/2/15

Y1 - 2003/2/15

N2 - Background. Experience with organ transplantation in patients with indolent lymphoma is limited, and it is unknown how the natural history of the disease is altered by chronic immunosuppressive therapy. Methods. A patient with type 1 diabetes and renal failure who underwent simultaneous kidney-pancreas transplantation was found to have stage IV small lymphocytic lymphoma at the time of transplantation. He received quadruple immunosuppressive therapy using interleukin (IL)-2 receptor antibody, tacrolimus, mycophenolate mofetil, and prednisone. Results. Patient is doing well 3 years posttransplant with excellent graft function of both the kidney and pancreas without any evidence of progression of the disease. Conclusion. Indolent lymphoma should not be considered an absolute contraindication to organ transplantation.

AB - Background. Experience with organ transplantation in patients with indolent lymphoma is limited, and it is unknown how the natural history of the disease is altered by chronic immunosuppressive therapy. Methods. A patient with type 1 diabetes and renal failure who underwent simultaneous kidney-pancreas transplantation was found to have stage IV small lymphocytic lymphoma at the time of transplantation. He received quadruple immunosuppressive therapy using interleukin (IL)-2 receptor antibody, tacrolimus, mycophenolate mofetil, and prednisone. Results. Patient is doing well 3 years posttransplant with excellent graft function of both the kidney and pancreas without any evidence of progression of the disease. Conclusion. Indolent lymphoma should not be considered an absolute contraindication to organ transplantation.

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Simultaneous kidney-pancreas transplantation in a patient with small lymphocytic lymphoma

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