Simultaneous chromosome 7 and 17 gain and sex chromosome loss provide evidence that renal metanephric adenoma is related to papillary renal cell carcinoma

James A. Brown, Kari L. Anderl, Thomas J. Borell, Junqi Qian, David G. Bostwick, Robert Brian Jenkins

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Purpose: Metanephric adenoma has recently been recognized as a unique renal tumor characterized by an unusual degree of cellular differentiation and maturation. We recently studied metanephric adenoma using metaphase analysis and observed concomitant chromosome Y loss and chromosome 7 and 17 gain. To determine if these chromosomal anomalies are consistently present in renal metanephric adenoma, we studied all 11 tumors in the pathology tissue registry at our institution using fluorescence in situ hybridization (FISH). Materials and Methods: FISH, using deoxyribonucleic acid probes for chromosomes 1, 7, 8, 17, X and Y, was performed in isolated nuclei from 11 paraffin embedded renal metanephric adenoma specimens. Results: Of the 11 tumors (73%) 8 demonstrated chromosome 7 and 17 gain by FISH, and the remaining 3 were found to have an apparently normal chromosomal content. Of the 8 tumors (75%) from men showed 6 chromosome 7 and 17 gain with Y chromosome loss. Of the 3 tumors (33%) from women 1 had chromosome 7 and 17 gain with X chromosome loss, while 1 had chromosome 7 and 17 gain without sex chromosome aneusomy. Metaphase analysis performed on 2 tumors revealed chromosome 7 and 17 gain and Y chromosome loss in l, and no apparent chromosome anomaly in the other, confirming the results of FISH analysis. Conclusions: FISH analysis of renal metanephric adenoma identified frequent chromosome 7 and 17 gain and sex chromosome loss. These results are consistent with a clonal neoplastic disorder in which chromosomes 7, 17, X and Y are likely to be involved in the pathogenesis of this tumor. These characteristic chromosomal alterations have also been observed in papillary renal cell adenoma and papillary renal cell carcinoma, providing evidence that these tumors may be related.

Original languageEnglish (US)
Pages (from-to)370-374
Number of pages5
JournalJournal of Urology
Volume158
Issue number2
DOIs
StatePublished - Aug 1997

Fingerprint

Chromosomes, Human, Pair 17
Sex Chromosomes
Chromosomes, Human, Pair 7
Renal Cell Carcinoma
Adenoma
Kidney
Fluorescence In Situ Hybridization
Y Chromosome
Neoplasms
Metaphase
Chromosomes, Human, Pair 1
X Chromosome
Paraffin
Registries
Chromosomes
Pathology
DNA

Keywords

  • Adenoma
  • Aneuploidy
  • DNA probes
  • Fluorescence in situ
  • Hybridization
  • Kidney

ASJC Scopus subject areas

  • Urology

Cite this

Simultaneous chromosome 7 and 17 gain and sex chromosome loss provide evidence that renal metanephric adenoma is related to papillary renal cell carcinoma. / Brown, James A.; Anderl, Kari L.; Borell, Thomas J.; Qian, Junqi; Bostwick, David G.; Jenkins, Robert Brian.

In: Journal of Urology, Vol. 158, No. 2, 08.1997, p. 370-374.

Research output: Contribution to journalArticle

Brown, James A. ; Anderl, Kari L. ; Borell, Thomas J. ; Qian, Junqi ; Bostwick, David G. ; Jenkins, Robert Brian. / Simultaneous chromosome 7 and 17 gain and sex chromosome loss provide evidence that renal metanephric adenoma is related to papillary renal cell carcinoma. In: Journal of Urology. 1997 ; Vol. 158, No. 2. pp. 370-374.
@article{570739c8b3054939acd81fcaed5f7693,
title = "Simultaneous chromosome 7 and 17 gain and sex chromosome loss provide evidence that renal metanephric adenoma is related to papillary renal cell carcinoma",
abstract = "Purpose: Metanephric adenoma has recently been recognized as a unique renal tumor characterized by an unusual degree of cellular differentiation and maturation. We recently studied metanephric adenoma using metaphase analysis and observed concomitant chromosome Y loss and chromosome 7 and 17 gain. To determine if these chromosomal anomalies are consistently present in renal metanephric adenoma, we studied all 11 tumors in the pathology tissue registry at our institution using fluorescence in situ hybridization (FISH). Materials and Methods: FISH, using deoxyribonucleic acid probes for chromosomes 1, 7, 8, 17, X and Y, was performed in isolated nuclei from 11 paraffin embedded renal metanephric adenoma specimens. Results: Of the 11 tumors (73{\%}) 8 demonstrated chromosome 7 and 17 gain by FISH, and the remaining 3 were found to have an apparently normal chromosomal content. Of the 8 tumors (75{\%}) from men showed 6 chromosome 7 and 17 gain with Y chromosome loss. Of the 3 tumors (33{\%}) from women 1 had chromosome 7 and 17 gain with X chromosome loss, while 1 had chromosome 7 and 17 gain without sex chromosome aneusomy. Metaphase analysis performed on 2 tumors revealed chromosome 7 and 17 gain and Y chromosome loss in l, and no apparent chromosome anomaly in the other, confirming the results of FISH analysis. Conclusions: FISH analysis of renal metanephric adenoma identified frequent chromosome 7 and 17 gain and sex chromosome loss. These results are consistent with a clonal neoplastic disorder in which chromosomes 7, 17, X and Y are likely to be involved in the pathogenesis of this tumor. These characteristic chromosomal alterations have also been observed in papillary renal cell adenoma and papillary renal cell carcinoma, providing evidence that these tumors may be related.",
keywords = "Adenoma, Aneuploidy, DNA probes, Fluorescence in situ, Hybridization, Kidney",
author = "Brown, {James A.} and Anderl, {Kari L.} and Borell, {Thomas J.} and Junqi Qian and Bostwick, {David G.} and Jenkins, {Robert Brian}",
year = "1997",
month = "8",
doi = "10.1016/S0022-5347(01)64482-3",
language = "English (US)",
volume = "158",
pages = "370--374",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Simultaneous chromosome 7 and 17 gain and sex chromosome loss provide evidence that renal metanephric adenoma is related to papillary renal cell carcinoma

AU - Brown, James A.

AU - Anderl, Kari L.

AU - Borell, Thomas J.

AU - Qian, Junqi

AU - Bostwick, David G.

AU - Jenkins, Robert Brian

PY - 1997/8

Y1 - 1997/8

N2 - Purpose: Metanephric adenoma has recently been recognized as a unique renal tumor characterized by an unusual degree of cellular differentiation and maturation. We recently studied metanephric adenoma using metaphase analysis and observed concomitant chromosome Y loss and chromosome 7 and 17 gain. To determine if these chromosomal anomalies are consistently present in renal metanephric adenoma, we studied all 11 tumors in the pathology tissue registry at our institution using fluorescence in situ hybridization (FISH). Materials and Methods: FISH, using deoxyribonucleic acid probes for chromosomes 1, 7, 8, 17, X and Y, was performed in isolated nuclei from 11 paraffin embedded renal metanephric adenoma specimens. Results: Of the 11 tumors (73%) 8 demonstrated chromosome 7 and 17 gain by FISH, and the remaining 3 were found to have an apparently normal chromosomal content. Of the 8 tumors (75%) from men showed 6 chromosome 7 and 17 gain with Y chromosome loss. Of the 3 tumors (33%) from women 1 had chromosome 7 and 17 gain with X chromosome loss, while 1 had chromosome 7 and 17 gain without sex chromosome aneusomy. Metaphase analysis performed on 2 tumors revealed chromosome 7 and 17 gain and Y chromosome loss in l, and no apparent chromosome anomaly in the other, confirming the results of FISH analysis. Conclusions: FISH analysis of renal metanephric adenoma identified frequent chromosome 7 and 17 gain and sex chromosome loss. These results are consistent with a clonal neoplastic disorder in which chromosomes 7, 17, X and Y are likely to be involved in the pathogenesis of this tumor. These characteristic chromosomal alterations have also been observed in papillary renal cell adenoma and papillary renal cell carcinoma, providing evidence that these tumors may be related.

AB - Purpose: Metanephric adenoma has recently been recognized as a unique renal tumor characterized by an unusual degree of cellular differentiation and maturation. We recently studied metanephric adenoma using metaphase analysis and observed concomitant chromosome Y loss and chromosome 7 and 17 gain. To determine if these chromosomal anomalies are consistently present in renal metanephric adenoma, we studied all 11 tumors in the pathology tissue registry at our institution using fluorescence in situ hybridization (FISH). Materials and Methods: FISH, using deoxyribonucleic acid probes for chromosomes 1, 7, 8, 17, X and Y, was performed in isolated nuclei from 11 paraffin embedded renal metanephric adenoma specimens. Results: Of the 11 tumors (73%) 8 demonstrated chromosome 7 and 17 gain by FISH, and the remaining 3 were found to have an apparently normal chromosomal content. Of the 8 tumors (75%) from men showed 6 chromosome 7 and 17 gain with Y chromosome loss. Of the 3 tumors (33%) from women 1 had chromosome 7 and 17 gain with X chromosome loss, while 1 had chromosome 7 and 17 gain without sex chromosome aneusomy. Metaphase analysis performed on 2 tumors revealed chromosome 7 and 17 gain and Y chromosome loss in l, and no apparent chromosome anomaly in the other, confirming the results of FISH analysis. Conclusions: FISH analysis of renal metanephric adenoma identified frequent chromosome 7 and 17 gain and sex chromosome loss. These results are consistent with a clonal neoplastic disorder in which chromosomes 7, 17, X and Y are likely to be involved in the pathogenesis of this tumor. These characteristic chromosomal alterations have also been observed in papillary renal cell adenoma and papillary renal cell carcinoma, providing evidence that these tumors may be related.

KW - Adenoma

KW - Aneuploidy

KW - DNA probes

KW - Fluorescence in situ

KW - Hybridization

KW - Kidney

UR - http://www.scopus.com/inward/record.url?scp=0030872093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030872093&partnerID=8YFLogxK

U2 - 10.1016/S0022-5347(01)64482-3

DO - 10.1016/S0022-5347(01)64482-3

M3 - Article

C2 - 9224305

AN - SCOPUS:0030872093

VL - 158

SP - 370

EP - 374

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 2

ER -