Simulated Online Adaptive Magnetic Resonance–Guided Stereotactic Body Radiation Therapy for the Treatment of Oligometastatic Disease of the Abdomen and Central Thorax: Characterization of Potential Advantages

Lauren Henke, Rojano Kashani, Deshan Yang, Tianyu Zhao, Olga Green, Lindsey Olsen, Vivian Rodriguez, H. Omar Wooten, H. Harold Li, Yanle Hu, Jeffrey Bradley, Clifford Robinson, Parag Parikh, Jeff Michalski, Sasa Mutic, Jeffrey R. Olsen

Research output: Contribution to journalArticle

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Abstract

Purpose To characterize potential advantages of online-adaptive magnetic resonance (MR)-guided stereotactic body radiation therapy (SBRT) to treat oligometastatic disease of the non-liver abdomen and central thorax. Methods and Materials Ten patients treated with RT for unresectable primary or oligometastatic disease of the non-liver abdomen (n=5) or central thorax (n=5) underwent imaging throughout treatment on a clinical MR image guided RT system. The SBRT plans were created on the basis of tumor/organ at risk (OAR) anatomy at initial computed tomography simulation (PI), and simulated adaptive plans were created on the basis of observed MR image set tumor/OAR “anatomy of the day” (PA). Each PA was planned under workflow constraints to simulate online-adaptive RT. Prescribed dose was 50 Gy/5 fractions, with goal coverage of 95% planning target volume (PTV) by 95% of the prescription, subject to hard OAR constraints. The PI was applied to each MR dataset and compared with PA to evaluate changes in dose delivered to tumor/OARs, with dose escalation when possible. Results Hard OAR constraints were met for all PIs based on anatomy from initial computed tomography simulation, and all PAs based on anatomy from each daily MR image set. Application of the PI to anatomy of the day caused OAR constraint violation in 19 of 30 cases. Adaptive planning increased PTV coverage in 21 of 30 cases, including 14 cases in which hard OAR constraints were violated by the nonadaptive plan. For 9 PA cases, decreased PTV coverage was required to meet hard OAR constraints that would have been violated in a nonadaptive setting. Conclusions Online-adaptive MRI-guided SBRT may allow PTV dose escalation and/or simultaneous OAR sparing compared with nonadaptive SBRT. A prospective clinical trial is underway at our institution to evaluate clinical outcomes of this technique.

Original languageEnglish (US)
Pages (from-to)1078-1086
Number of pages9
JournalInternational Journal of Radiation Oncology Biology Physics
Volume96
Issue number5
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

Fingerprint

Organs at Risk
thorax
abdomen
organs
Abdomen
radiation therapy
Radiotherapy
Thorax
anatomy
magnetic resonance
planning
Anatomy
Magnetic Resonance Spectroscopy
dosage
tumors
Therapeutics
Liver Diseases
tomography
Tomography
Neoplasms

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Simulated Online Adaptive Magnetic Resonance–Guided Stereotactic Body Radiation Therapy for the Treatment of Oligometastatic Disease of the Abdomen and Central Thorax : Characterization of Potential Advantages. / Henke, Lauren; Kashani, Rojano; Yang, Deshan; Zhao, Tianyu; Green, Olga; Olsen, Lindsey; Rodriguez, Vivian; Wooten, H. Omar; Li, H. Harold; Hu, Yanle; Bradley, Jeffrey; Robinson, Clifford; Parikh, Parag; Michalski, Jeff; Mutic, Sasa; Olsen, Jeffrey R.

In: International Journal of Radiation Oncology Biology Physics, Vol. 96, No. 5, 01.12.2016, p. 1078-1086.

Research output: Contribution to journalArticle

Henke, L, Kashani, R, Yang, D, Zhao, T, Green, O, Olsen, L, Rodriguez, V, Wooten, HO, Li, HH, Hu, Y, Bradley, J, Robinson, C, Parikh, P, Michalski, J, Mutic, S & Olsen, JR 2016, 'Simulated Online Adaptive Magnetic Resonance–Guided Stereotactic Body Radiation Therapy for the Treatment of Oligometastatic Disease of the Abdomen and Central Thorax: Characterization of Potential Advantages', International Journal of Radiation Oncology Biology Physics, vol. 96, no. 5, pp. 1078-1086. https://doi.org/10.1016/j.ijrobp.2016.08.036
Henke, Lauren ; Kashani, Rojano ; Yang, Deshan ; Zhao, Tianyu ; Green, Olga ; Olsen, Lindsey ; Rodriguez, Vivian ; Wooten, H. Omar ; Li, H. Harold ; Hu, Yanle ; Bradley, Jeffrey ; Robinson, Clifford ; Parikh, Parag ; Michalski, Jeff ; Mutic, Sasa ; Olsen, Jeffrey R. / Simulated Online Adaptive Magnetic Resonance–Guided Stereotactic Body Radiation Therapy for the Treatment of Oligometastatic Disease of the Abdomen and Central Thorax : Characterization of Potential Advantages. In: International Journal of Radiation Oncology Biology Physics. 2016 ; Vol. 96, No. 5. pp. 1078-1086.
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abstract = "Purpose To characterize potential advantages of online-adaptive magnetic resonance (MR)-guided stereotactic body radiation therapy (SBRT) to treat oligometastatic disease of the non-liver abdomen and central thorax. Methods and Materials Ten patients treated with RT for unresectable primary or oligometastatic disease of the non-liver abdomen (n=5) or central thorax (n=5) underwent imaging throughout treatment on a clinical MR image guided RT system. The SBRT plans were created on the basis of tumor/organ at risk (OAR) anatomy at initial computed tomography simulation (PI), and simulated adaptive plans were created on the basis of observed MR image set tumor/OAR “anatomy of the day” (PA). Each PA was planned under workflow constraints to simulate online-adaptive RT. Prescribed dose was 50 Gy/5 fractions, with goal coverage of 95{\%} planning target volume (PTV) by 95{\%} of the prescription, subject to hard OAR constraints. The PI was applied to each MR dataset and compared with PA to evaluate changes in dose delivered to tumor/OARs, with dose escalation when possible. Results Hard OAR constraints were met for all PIs based on anatomy from initial computed tomography simulation, and all PAs based on anatomy from each daily MR image set. Application of the PI to anatomy of the day caused OAR constraint violation in 19 of 30 cases. Adaptive planning increased PTV coverage in 21 of 30 cases, including 14 cases in which hard OAR constraints were violated by the nonadaptive plan. For 9 PA cases, decreased PTV coverage was required to meet hard OAR constraints that would have been violated in a nonadaptive setting. Conclusions Online-adaptive MRI-guided SBRT may allow PTV dose escalation and/or simultaneous OAR sparing compared with nonadaptive SBRT. A prospective clinical trial is underway at our institution to evaluate clinical outcomes of this technique.",
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T2 - Characterization of Potential Advantages

AU - Henke, Lauren

AU - Kashani, Rojano

AU - Yang, Deshan

AU - Zhao, Tianyu

AU - Green, Olga

AU - Olsen, Lindsey

AU - Rodriguez, Vivian

AU - Wooten, H. Omar

AU - Li, H. Harold

AU - Hu, Yanle

AU - Bradley, Jeffrey

AU - Robinson, Clifford

AU - Parikh, Parag

AU - Michalski, Jeff

AU - Mutic, Sasa

AU - Olsen, Jeffrey R.

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N2 - Purpose To characterize potential advantages of online-adaptive magnetic resonance (MR)-guided stereotactic body radiation therapy (SBRT) to treat oligometastatic disease of the non-liver abdomen and central thorax. Methods and Materials Ten patients treated with RT for unresectable primary or oligometastatic disease of the non-liver abdomen (n=5) or central thorax (n=5) underwent imaging throughout treatment on a clinical MR image guided RT system. The SBRT plans were created on the basis of tumor/organ at risk (OAR) anatomy at initial computed tomography simulation (PI), and simulated adaptive plans were created on the basis of observed MR image set tumor/OAR “anatomy of the day” (PA). Each PA was planned under workflow constraints to simulate online-adaptive RT. Prescribed dose was 50 Gy/5 fractions, with goal coverage of 95% planning target volume (PTV) by 95% of the prescription, subject to hard OAR constraints. The PI was applied to each MR dataset and compared with PA to evaluate changes in dose delivered to tumor/OARs, with dose escalation when possible. Results Hard OAR constraints were met for all PIs based on anatomy from initial computed tomography simulation, and all PAs based on anatomy from each daily MR image set. Application of the PI to anatomy of the day caused OAR constraint violation in 19 of 30 cases. Adaptive planning increased PTV coverage in 21 of 30 cases, including 14 cases in which hard OAR constraints were violated by the nonadaptive plan. For 9 PA cases, decreased PTV coverage was required to meet hard OAR constraints that would have been violated in a nonadaptive setting. Conclusions Online-adaptive MRI-guided SBRT may allow PTV dose escalation and/or simultaneous OAR sparing compared with nonadaptive SBRT. A prospective clinical trial is underway at our institution to evaluate clinical outcomes of this technique.

AB - Purpose To characterize potential advantages of online-adaptive magnetic resonance (MR)-guided stereotactic body radiation therapy (SBRT) to treat oligometastatic disease of the non-liver abdomen and central thorax. Methods and Materials Ten patients treated with RT for unresectable primary or oligometastatic disease of the non-liver abdomen (n=5) or central thorax (n=5) underwent imaging throughout treatment on a clinical MR image guided RT system. The SBRT plans were created on the basis of tumor/organ at risk (OAR) anatomy at initial computed tomography simulation (PI), and simulated adaptive plans were created on the basis of observed MR image set tumor/OAR “anatomy of the day” (PA). Each PA was planned under workflow constraints to simulate online-adaptive RT. Prescribed dose was 50 Gy/5 fractions, with goal coverage of 95% planning target volume (PTV) by 95% of the prescription, subject to hard OAR constraints. The PI was applied to each MR dataset and compared with PA to evaluate changes in dose delivered to tumor/OARs, with dose escalation when possible. Results Hard OAR constraints were met for all PIs based on anatomy from initial computed tomography simulation, and all PAs based on anatomy from each daily MR image set. Application of the PI to anatomy of the day caused OAR constraint violation in 19 of 30 cases. Adaptive planning increased PTV coverage in 21 of 30 cases, including 14 cases in which hard OAR constraints were violated by the nonadaptive plan. For 9 PA cases, decreased PTV coverage was required to meet hard OAR constraints that would have been violated in a nonadaptive setting. Conclusions Online-adaptive MRI-guided SBRT may allow PTV dose escalation and/or simultaneous OAR sparing compared with nonadaptive SBRT. A prospective clinical trial is underway at our institution to evaluate clinical outcomes of this technique.

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