TY - GEN
T1 - Simulated imaging of atherosclerotic & radiofrequency ablation lesions using phase subtraction
AU - Jameson, John R.
AU - Holmes, David R.
AU - Buhrow, Benjamin R.
AU - Daniel, Erik S.
AU - Gilbert, Barry K.
AU - Haider, Clifton R.
N1 - Publisher Copyright:
© 2015 IEEE.
PY - 2015/11/4
Y1 - 2015/11/4
N2 - Cardiovascular diseases are the main cause of death worldwide. Atherosclerosis and atrial fibrillation are structural and electrical pathophysiology, respectively, that can lead to acute events such as stroke or myocardial infarction. We used particle-based Monte Carlo methods to simulate X-ray phase imaging of atherosclerotic plaque types IV-VIII in the aorta, iliac, and coronary arteries. We also assessed scar lesion development in radiofrequency catheter ablation treatment of atrial fibrillation by simulating lesions 2, 5, 10, 30, and 60 days post-procedure. For both applications, we found high signal-to-noise and contrast-to-noise ratios in all lesions. These results suggest that X-ray phase imaging is a viable technique for non-invasive quantitative cardiovascular lesion characterization.
AB - Cardiovascular diseases are the main cause of death worldwide. Atherosclerosis and atrial fibrillation are structural and electrical pathophysiology, respectively, that can lead to acute events such as stroke or myocardial infarction. We used particle-based Monte Carlo methods to simulate X-ray phase imaging of atherosclerotic plaque types IV-VIII in the aorta, iliac, and coronary arteries. We also assessed scar lesion development in radiofrequency catheter ablation treatment of atrial fibrillation by simulating lesions 2, 5, 10, 30, and 60 days post-procedure. For both applications, we found high signal-to-noise and contrast-to-noise ratios in all lesions. These results suggest that X-ray phase imaging is a viable technique for non-invasive quantitative cardiovascular lesion characterization.
UR - http://www.scopus.com/inward/record.url?scp=84953320025&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84953320025&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2015.7319669
DO - 10.1109/EMBC.2015.7319669
M3 - Conference contribution
C2 - 26737569
AN - SCOPUS:84953320025
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 5630
EP - 5633
BT - 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Y2 - 25 August 2015 through 29 August 2015
ER -