TY - JOUR
T1 - Simple anthropometric measures identify fasting hyperinsulinemia and clustering of cardiovascular risk factors in Asian Indian adolescents
AU - Misra, Anoop
AU - Madhavan, Malini
AU - Vikram, Naval K.
AU - Pandey, Ravindra M.
AU - Dhingra, Vibha
AU - Luthra, Kalpana
N1 - Funding Information:
This study was fully supported by a financial grant from the Department of Science and Technology, Ministry of Science and Technology, Government of New Delhi, India. Mr Ramesh Giri assisted in anthropometry and body fat measurement. The cooperation of the children who took part in the study and the help extended by the principals, teachers, and staff of the various schools and colleges where the study was conducted are greatly appreciated.
PY - 2006/12
Y1 - 2006/12
N2 - Correlations of easily measurable parameters of obesity (body mass index [BMI], waist circumference [WC], and subscapular skinfold thickness) with fasting hyperinsulinemia and cardiovascular risk factors (CRFs) have not been investigated in adolescents. We evaluated the screening performance of 3 anthropometric measurements, BMI, WC, and subscapular skinfold thickness, in identifying fasting hyperinsulinemia and clustering of CRFs in 680 male and 521 female adolescents and young adults aged 14 to 18 years in a cross-sectional population survey. CRFs considered were hypercholesterolemia, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol, impaired fasting blood glucose, hypertension, and fasting hyperinsulinemia. The ability of the anthropometric measurements to identify the clustering of CRFs without (cluster 1) and with fasting hyperinsulinemia (cluster 2), and fasting hyperinsulinemia alone was evaluated. BMI, WC, and subscapular skinfold thickness identified the clustering of CRFs and fasting hyperinsulinemia better in males than in females. Among individual risk factors, WC was better in identifying the presence of 3 or more risk factors in cluster 1 for both males and females, and in cluster 2 in females. Subscapular skinfold thickness was better than BMI and WC in identifying hyperinsulinemia in males, and the presence of 3 or more risk factors in cluster 2 in females. All 3 measurements were more accurate in identifying fasting hyperinsulinemia than presence of 3 or more CRFs in either cluster 1 or cluster 2 with higher odds ratio for males. This study shows gender differences in identification of insulin resistance and clustering of CRFs by using simple anthropometric parameters in Asian Indian adolescents. These simple measurements are useful for preventing and predicting cardiovascular risk and for generating a correct definition of the metabolic syndrome.
AB - Correlations of easily measurable parameters of obesity (body mass index [BMI], waist circumference [WC], and subscapular skinfold thickness) with fasting hyperinsulinemia and cardiovascular risk factors (CRFs) have not been investigated in adolescents. We evaluated the screening performance of 3 anthropometric measurements, BMI, WC, and subscapular skinfold thickness, in identifying fasting hyperinsulinemia and clustering of CRFs in 680 male and 521 female adolescents and young adults aged 14 to 18 years in a cross-sectional population survey. CRFs considered were hypercholesterolemia, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol, impaired fasting blood glucose, hypertension, and fasting hyperinsulinemia. The ability of the anthropometric measurements to identify the clustering of CRFs without (cluster 1) and with fasting hyperinsulinemia (cluster 2), and fasting hyperinsulinemia alone was evaluated. BMI, WC, and subscapular skinfold thickness identified the clustering of CRFs and fasting hyperinsulinemia better in males than in females. Among individual risk factors, WC was better in identifying the presence of 3 or more risk factors in cluster 1 for both males and females, and in cluster 2 in females. Subscapular skinfold thickness was better than BMI and WC in identifying hyperinsulinemia in males, and the presence of 3 or more risk factors in cluster 2 in females. All 3 measurements were more accurate in identifying fasting hyperinsulinemia than presence of 3 or more CRFs in either cluster 1 or cluster 2 with higher odds ratio for males. This study shows gender differences in identification of insulin resistance and clustering of CRFs by using simple anthropometric parameters in Asian Indian adolescents. These simple measurements are useful for preventing and predicting cardiovascular risk and for generating a correct definition of the metabolic syndrome.
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U2 - 10.1016/j.metabol.2006.06.029
DO - 10.1016/j.metabol.2006.06.029
M3 - Article
C2 - 17142126
AN - SCOPUS:34247566722
SN - 0026-0495
VL - 55
SP - 1569
EP - 1573
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 12
ER -