Simple and reproducible hepatectomy in the mouse using the clip technique

Tomohide Hori, Norifumi Ohashi, Feng Chen, Ann Marie T. Baine, Lindsay B. Gardner, Toshiyuki Hata, Shinji Uemoto, Justin H. Nguyen

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings. RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data.

Original languageEnglish (US)
Pages (from-to)2767-2774
Number of pages8
JournalWorld journal of gastroenterology
Volume18
Issue number22
DOIs
StatePublished - Jun 2012

Keywords

  • Animal model
  • Clip
  • Hepatectomy
  • Microsurgery
  • Surgical technique

ASJC Scopus subject areas

  • Gastroenterology

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    Hori, T., Ohashi, N., Chen, F., Baine, A. M. T., Gardner, L. B., Hata, T., Uemoto, S., & Nguyen, J. H. (2012). Simple and reproducible hepatectomy in the mouse using the clip technique. World journal of gastroenterology, 18(22), 2767-2774. https://doi.org/10.3748/wjg.v18.i22.2767