Simple and reproducible hepatectomy in the mouse using the clip technique

Tomohide Hori, Norifumi Ohashi, Feng Chen, Ann Marie T Baine, Lindsay B. Gardner, Toshiyuki Hata, Shinji Uemoto, Justin H Nguyen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings. RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data.

Original languageEnglish (US)
Pages (from-to)2767-2774
Number of pages8
JournalWorld Journal of Gastroenterology
Volume18
Issue number22
DOIs
StatePublished - Jun 2012

Fingerprint

Hepatectomy
Surgical Instruments
Learning Curve
Operative Time
Anatomic Models
Suture Techniques
Liver

Keywords

  • Animal model
  • Clip
  • Hepatectomy
  • Microsurgery
  • Surgical technique

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Simple and reproducible hepatectomy in the mouse using the clip technique. / Hori, Tomohide; Ohashi, Norifumi; Chen, Feng; Baine, Ann Marie T; Gardner, Lindsay B.; Hata, Toshiyuki; Uemoto, Shinji; Nguyen, Justin H.

In: World Journal of Gastroenterology, Vol. 18, No. 22, 06.2012, p. 2767-2774.

Research output: Contribution to journalArticle

Hori, T, Ohashi, N, Chen, F, Baine, AMT, Gardner, LB, Hata, T, Uemoto, S & Nguyen, JH 2012, 'Simple and reproducible hepatectomy in the mouse using the clip technique', World Journal of Gastroenterology, vol. 18, no. 22, pp. 2767-2774. https://doi.org/10.3748/wjg.v18.i22.2767
Hori, Tomohide ; Ohashi, Norifumi ; Chen, Feng ; Baine, Ann Marie T ; Gardner, Lindsay B. ; Hata, Toshiyuki ; Uemoto, Shinji ; Nguyen, Justin H. / Simple and reproducible hepatectomy in the mouse using the clip technique. In: World Journal of Gastroenterology. 2012 ; Vol. 18, No. 22. pp. 2767-2774.
@article{5a153d9033724cc7b1846a920ef4e011,
title = "Simple and reproducible hepatectomy in the mouse using the clip technique",
abstract = "AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70{\%}. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings. RESULTS: According to anatomical results, models with 75{\%}, 80{\%}, and 90{\%} hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data.",
keywords = "Animal model, Clip, Hepatectomy, Microsurgery, Surgical technique",
author = "Tomohide Hori and Norifumi Ohashi and Feng Chen and Baine, {Ann Marie T} and Gardner, {Lindsay B.} and Toshiyuki Hata and Shinji Uemoto and Nguyen, {Justin H}",
year = "2012",
month = "6",
doi = "10.3748/wjg.v18.i22.2767",
language = "English (US)",
volume = "18",
pages = "2767--2774",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "22",

}

TY - JOUR

T1 - Simple and reproducible hepatectomy in the mouse using the clip technique

AU - Hori, Tomohide

AU - Ohashi, Norifumi

AU - Chen, Feng

AU - Baine, Ann Marie T

AU - Gardner, Lindsay B.

AU - Hata, Toshiyuki

AU - Uemoto, Shinji

AU - Nguyen, Justin H

PY - 2012/6

Y1 - 2012/6

N2 - AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings. RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data.

AB - AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings. RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data.

KW - Animal model

KW - Clip

KW - Hepatectomy

KW - Microsurgery

KW - Surgical technique

UR - http://www.scopus.com/inward/record.url?scp=84861732858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861732858&partnerID=8YFLogxK

U2 - 10.3748/wjg.v18.i22.2767

DO - 10.3748/wjg.v18.i22.2767

M3 - Article

C2 - 22719184

AN - SCOPUS:84861732858

VL - 18

SP - 2767

EP - 2774

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 22

ER -