Similar survival with breast conservation therapy or mastectomy in the management of young women with early-stage breast cancer

Usama Mahmood, Christopher Morris, Geoffrey Neuner, Matthew Koshy, Susan Kesmodel, Robert Buras, Saranya Chumsri, Ting Bao, Katherine Tkaczuk, Steven Feigenberg

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Purpose: To evaluate survival outcomes of young women with early-stage breast cancer treated with breast conservation therapy (BCT) or mastectomy, using a large, population-based database. Methods and Materials: Using the Surveillance, Epidemiology, and End Results (SEER) database, information was obtained for all female patients, ages 20 to 39 years old, diagnosed with T1-2 N0-1 M0 breast cancer between 1990 and 2007, who underwent either BCT (lumpectomy and radiation treatment) or mastectomy. Multivariable and matched pair analyses were performed to compare overall survival (OS) and cause-specific survival (CSS) of patients undergoing BCT and mastectomy. Results: A total of 14,764 women were identified, of whom 45% received BCT and 55% received mastectomy. Median follow-up was 5.7 years (range, 0.5-17.9 years). After we accounted for all patient and tumor characteristics, multivariable analysis found that BCT resulted in OS (hazard ratio [HR], 0.93; 95% confidence interval [CI], 0.83-1.04; p = 0.16) and CSS (HR, 0.93; CI, 0.83-1.05; p = 0.26) similar to that of mastectomy. Matched pair analysis, including 4,644 BCT and mastectomy patients, confirmed no difference in OS or CSS: the 5-, 10-, and15-year OS rates for BCT and mastectomy were 92.5%, 83.5%, and 77.0% and 91.9%, 83.6%, and 79.1%, respectively (p = 0.99), and the 5-, 10-, and 15-year CSS rates for BCT and mastectomy were 93.3%, 85.5%, and 79.9% and 92.5%, 85.5%, and 81.9%, respectively (p = 0.88). Conclusions: Our analysis of this population-based database suggests that young women with early-stage breast cancer have similar survival rates whether treated with BCT or mastectomy. These patients should be counseled appropriately regarding their treatment options and should not choose a mastectomy based on the assumption of improved survival.

Original languageEnglish (US)
Pages (from-to)1387-1393
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume83
Issue number5
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Fingerprint

Segmental Mastectomy
Mastectomy
breast
conservation
therapy
cancer
Breast Neoplasms
Survival
Matched-Pair Analysis
Survival Rate
Databases
causes
hazards
confidence
Confidence Intervals
epidemiology
intervals
Population
surveillance
Epidemiology

Keywords

  • Breast cancer
  • Breast conservation therapy
  • Mastectomy
  • SEER database
  • Young women

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

Similar survival with breast conservation therapy or mastectomy in the management of young women with early-stage breast cancer. / Mahmood, Usama; Morris, Christopher; Neuner, Geoffrey; Koshy, Matthew; Kesmodel, Susan; Buras, Robert; Chumsri, Saranya; Bao, Ting; Tkaczuk, Katherine; Feigenberg, Steven.

In: International Journal of Radiation Oncology Biology Physics, Vol. 83, No. 5, 01.08.2012, p. 1387-1393.

Research output: Contribution to journalArticle

Mahmood, Usama ; Morris, Christopher ; Neuner, Geoffrey ; Koshy, Matthew ; Kesmodel, Susan ; Buras, Robert ; Chumsri, Saranya ; Bao, Ting ; Tkaczuk, Katherine ; Feigenberg, Steven. / Similar survival with breast conservation therapy or mastectomy in the management of young women with early-stage breast cancer. In: International Journal of Radiation Oncology Biology Physics. 2012 ; Vol. 83, No. 5. pp. 1387-1393.
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AU - Kesmodel, Susan

AU - Buras, Robert

AU - Chumsri, Saranya

AU - Bao, Ting

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AU - Feigenberg, Steven

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N2 - Purpose: To evaluate survival outcomes of young women with early-stage breast cancer treated with breast conservation therapy (BCT) or mastectomy, using a large, population-based database. Methods and Materials: Using the Surveillance, Epidemiology, and End Results (SEER) database, information was obtained for all female patients, ages 20 to 39 years old, diagnosed with T1-2 N0-1 M0 breast cancer between 1990 and 2007, who underwent either BCT (lumpectomy and radiation treatment) or mastectomy. Multivariable and matched pair analyses were performed to compare overall survival (OS) and cause-specific survival (CSS) of patients undergoing BCT and mastectomy. Results: A total of 14,764 women were identified, of whom 45% received BCT and 55% received mastectomy. Median follow-up was 5.7 years (range, 0.5-17.9 years). After we accounted for all patient and tumor characteristics, multivariable analysis found that BCT resulted in OS (hazard ratio [HR], 0.93; 95% confidence interval [CI], 0.83-1.04; p = 0.16) and CSS (HR, 0.93; CI, 0.83-1.05; p = 0.26) similar to that of mastectomy. Matched pair analysis, including 4,644 BCT and mastectomy patients, confirmed no difference in OS or CSS: the 5-, 10-, and15-year OS rates for BCT and mastectomy were 92.5%, 83.5%, and 77.0% and 91.9%, 83.6%, and 79.1%, respectively (p = 0.99), and the 5-, 10-, and 15-year CSS rates for BCT and mastectomy were 93.3%, 85.5%, and 79.9% and 92.5%, 85.5%, and 81.9%, respectively (p = 0.88). Conclusions: Our analysis of this population-based database suggests that young women with early-stage breast cancer have similar survival rates whether treated with BCT or mastectomy. These patients should be counseled appropriately regarding their treatment options and should not choose a mastectomy based on the assumption of improved survival.

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