Silo-Filler's disease

W. W. Douglas, N. G G Hepper, T. V. Colby

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Between 1955 and 1987, 17 patients were examined at the Mayo Clinic shortly after exposure to silo gas. All exposures had occurred in conventional top-unloading silos. Acute lung injury occurred in 11 patients, 1 of whom died; early diffuse alveolar damage with hyaline membranes and hemorrhagic pulmonary edema and acute edema of the airways were found at autopsy. In one patient, hypoxemia and transient obstruction of the airways developed, but no pulmonary infiltrates were noted. One patient had symptoms for 5 weeks and diffuse confluent pulmonary infiltrates; many years later, chronic obstructive pulmonary disease developed (he had, however, been a heavy smoker before exposure). Bronchiolitis obliterans was not observed in the other patients, probably because of less severe exposure or early corticosteroid therapy. Prophylactic corticosteroid therapy is advised for workers who have been exposed to silo gas. The management of patients with established acute lung injury is reviewed. Previously unreported patterns of exposure to silo gas in conventional silos are described, and recommendations for avoiding exposure are suggested.

Original languageEnglish (US)
Pages (from-to)291-304
Number of pages14
JournalMayo Clinic Proceedings
Volume64
Issue number3
StatePublished - 1989

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Silo Filler's Disease
Acute Lung Injury
Gases
Adrenal Cortex Hormones
Bronchiolitis Obliterans
Lung
Hyalin
Pulmonary Edema
Airway Obstruction
Secondary Prevention
Chronic Obstructive Pulmonary Disease
Autopsy
Edema
Membranes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Douglas, W. W., Hepper, N. G. G., & Colby, T. V. (1989). Silo-Filler's disease. Mayo Clinic Proceedings, 64(3), 291-304.

Silo-Filler's disease. / Douglas, W. W.; Hepper, N. G G; Colby, T. V.

In: Mayo Clinic Proceedings, Vol. 64, No. 3, 1989, p. 291-304.

Research output: Contribution to journalArticle

Douglas, WW, Hepper, NGG & Colby, TV 1989, 'Silo-Filler's disease', Mayo Clinic Proceedings, vol. 64, no. 3, pp. 291-304.
Douglas WW, Hepper NGG, Colby TV. Silo-Filler's disease. Mayo Clinic Proceedings. 1989;64(3):291-304.
Douglas, W. W. ; Hepper, N. G G ; Colby, T. V. / Silo-Filler's disease. In: Mayo Clinic Proceedings. 1989 ; Vol. 64, No. 3. pp. 291-304.
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