Silencing of type I-phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion

Siyu Cao, Chunhua Chen, Junli Xue, Yan Huang, Xiaofeng Yang, Kun Ling

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Metastasis is the major cause of death in ovarian cancer patients. Given that the molecular mechanism underlying metastasis formation is critical for improving therapeutic development and clinical treatment, it must be fully understood. Recent studies have revealed that lipid kinase type I-phosphatidylinositol phosphate kinase (PIPKI-) participates in the metastasis of breast cancer and colon cancer by regulating cell migration and invasion. However, its role in the progression of ovarian cancer is unclear. Here we showed that PIPKI-expression is upregulated in multiple epithelial ovarian cancer cell lines. Silencing of PIPKI-impaired PI3K/AKT signaling and inhibited the aggressive behaviors of epithelial ovarian cancer cells, including proliferation, migration and invasion. Moreover, we found that PIPKI-was required for the activation of signal transducer and activator of transcription 3 (STAT3) in epithelial ovarian cancer cells, indicating that STAT3 may also be engaged in the PIPKI-dependent aggressiveness of epithelial ovarian cancer cells. Our results, for the first time, identified PIPKI-as a novel regulator in epithelial ovarian cancer cells that promotes cell proliferation, migration and invasion by activating multiple signaling pathways. Therefore, we propose that PIPKI-could potentially be a therapeutic target for the early detection and treatment of epithelial ovarian cancer. Further studies employing in vivo models are necessary to test this possibility.

Original languageEnglish (US)
Pages (from-to)253-262
Number of pages10
JournalOncology reports
Volume38
Issue number1
DOIs
StatePublished - 2017

Keywords

  • Invasion
  • Migration
  • Ovarian cancer
  • PI3K/AKT
  • Proliferation
  • STAT3
  • Type I-phosphatidylinositol phosphate kinase

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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