Significance of serum bombesin as a tumor marker for small-cell lung carcinoma

Kayoko Tateishi, George G. Klee

Research output: Contribution to journalArticle

Abstract

Using a radioimmunoassay, we studied the significance of bombesin as a specific marker for small-cellcarcinoma of the lung (SCCL). Bombesin-like immunoreactivity (BLI) was detectable in serum 4 of 15 patients with SCCL (27%), but was undetectable in serum of ail 15 healthy subjects. BLI was also detectable in 7 of 31 patients with non-SCCL tumors (23%) and 4 of 31 patients with other types of lung disease (13%). The present results indicate that bombesin is unlikely to be a specific marker for the early detection of SCCL though bombesin could be formed by SCCL and its metastasis, and might be released into the circulation.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalJapanese Journal of Clinical Chemistry
Volume14
Issue number2
DOIs
StatePublished - 1985

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Bombesin
Small Cell Lung Carcinoma
Tumor Biomarkers
Cells
Lung
Serum
Pulmonary diseases
Lung Diseases
Radioimmunoassay
Tumors
Healthy Volunteers
Neoplasm Metastasis
Neoplasms

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Significance of serum bombesin as a tumor marker for small-cell lung carcinoma. / Tateishi, Kayoko; Klee, George G.

In: Japanese Journal of Clinical Chemistry, Vol. 14, No. 2, 1985, p. 127-131.

Research output: Contribution to journalArticle

Tateishi, Kayoko ; Klee, George G. / Significance of serum bombesin as a tumor marker for small-cell lung carcinoma. In: Japanese Journal of Clinical Chemistry. 1985 ; Vol. 14, No. 2. pp. 127-131.
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