Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence

Mathew George, Philippe Paci, Timucin Taner

Research output: Contribution to journalReview article

Abstract

This article reviews the current evidence and knowledge of progressive liver fibrosis after pediatric liver transplantation. This often-silent histologic finding is common in long-term survivors and may lead to allograft dysfunction in advanced stages. Surveillance through protocolized liver allograft biopsy remains the gold standard for diagnosis, and recent evidence suggests that chronic inflammation precedes fibrosis.

Original languageEnglish (US)
Pages (from-to)1987-1992
Number of pages6
JournalWorld journal of gastroenterology
Volume26
Issue number17
DOIs
StatePublished - May 7 2020

Keywords

  • Allograft fibrosis
  • Chronic rejection
  • Immunosuppression
  • Liver allograft
  • Pediatric liver transplant
  • Portal inflammation

ASJC Scopus subject areas

  • Gastroenterology

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