Significance of percutaneous needle biopsy in patients with multiple pulmonary nodules and a single known primary malignancy

E. F. Patz, J. Fidler, M. Knelson, S. Paine, P. Goodman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: To determine the necessity of percutaneous lung biopsy in patients with a single known primary malignancy and multiple pulmonary nodules. Design: Retrospective study. Setting: Tertiary care university hospital. Results: We reviewed all percutaneous lung biopsy specimens over a 6-year period. One hundred forty-six patients with a single known primary malignancy and multiple pulmonary nodules had biopsies performed up to 19 years following diagnosis of the primary neoplasm. One hundred thirty-seven biopsy specimens (93.8%) were positive for metastases. Eight patients (5.5%) had a nondiagnostic biopsy specimen; however, subsequent imaging studies and the clinical course strongly suggested diffuse metastatic disease. One patient (<1%) with breast carcinoma developed nodules 3 years after initial diagnosis and had resolution without a definitive diagnosis or therapy. Conclusion: Patients with a single known primary malignancy and multiple pulmonary nodules who present for percutaneous needle biopsy will have pulmonary metastases in the vast majority of cases. Biopsy in these patients rarely changes the clinical course as other diagnoses are rarely established.

Original languageEnglish (US)
Pages (from-to)601-604
Number of pages4
JournalChest
Volume107
Issue number3
StatePublished - 1995
Externally publishedYes

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Multiple Pulmonary Nodules
Needle Biopsy
Biopsy
Neoplasms
Lung
Neoplasm Metastasis
Tertiary Healthcare
Retrospective Studies
Breast Neoplasms

Keywords

  • lung biopsy
  • pulmonary metastases
  • pulmonary nodules

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Patz, E. F., Fidler, J., Knelson, M., Paine, S., & Goodman, P. (1995). Significance of percutaneous needle biopsy in patients with multiple pulmonary nodules and a single known primary malignancy. Chest, 107(3), 601-604.

Significance of percutaneous needle biopsy in patients with multiple pulmonary nodules and a single known primary malignancy. / Patz, E. F.; Fidler, J.; Knelson, M.; Paine, S.; Goodman, P.

In: Chest, Vol. 107, No. 3, 1995, p. 601-604.

Research output: Contribution to journalArticle

Patz, EF, Fidler, J, Knelson, M, Paine, S & Goodman, P 1995, 'Significance of percutaneous needle biopsy in patients with multiple pulmonary nodules and a single known primary malignancy', Chest, vol. 107, no. 3, pp. 601-604.
Patz, E. F. ; Fidler, J. ; Knelson, M. ; Paine, S. ; Goodman, P. / Significance of percutaneous needle biopsy in patients with multiple pulmonary nodules and a single known primary malignancy. In: Chest. 1995 ; Vol. 107, No. 3. pp. 601-604.
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