Signaling from novel splice variants of hormone receptors in cancer

Wei Qun Ding, Laurence J. Miller

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A number of splice variants of hormone receptors have recently been described in malignant neoplasms. Signaling by these novel receptor isoforms differ from their wild type counterparts, raising interesting questions as to possible roles in the initiation, progression, and metastatic potential of various tumors. This review summarizes recent findings on the signaling of novel variants of hormone receptors, including human HER-2/neu, the secretin receptor, the CCK-B/gastrin receptor and fibroblast growth factor receptor-2.

Original languageEnglish (US)
Pages (from-to)31-39
Number of pages9
JournalInternational Journal of Gastrointestinal Cancer
Volume31
Issue number1-3
DOIs
StatePublished - 2002

Keywords

  • CCK-B receptor
  • Fibroblast growth factor receptor
  • HER-2/neu
  • Secretin receptor
  • Signaling
  • Splice variant

ASJC Scopus subject areas

  • Oncology
  • Endocrinology
  • Gastroenterology

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