Signal transduction through the T-cell antigen receptor

Robert T. Abraham, Larry M. Karnitz, J. Paul Secrist, Paul J. Leibson

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The mechanism by which ligand binding to the T-cell antigen receptor triggers the T-cell activation program has long been one of the most fascinating questions in lymphocyte biology. Here, we review recent insights into the transmembrane signaling functions of this multisubunit receptor complex.

Original languageEnglish (US)
Pages (from-to)434-438
Number of pages5
JournalTrends in biochemical sciences
Issue number10
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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