Signal transduction inhibitor therapy for lymphoma.

Thomas Elmer Witzig, Mamta Gupta

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Current research in lymphoma is focused on two areas of lymphoma biology-the signal transduction pathways used to maintain the growth of malignant lymphocytes and the role of the tumor microenvironment in lymphoma growth and survival. This review focuses on three signaling pathways: the phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway, the B-cell receptor/spleen tyrosine kinase (BCR/Syk) pathway, and the protein kinase C-beta (PKC-β) pathway, known to be important to lymphoma cells. The mTOR inhibitors temsirolimus and everolimus have demonstrated antitumor activity in all types of lymphoma, the Syk inhibitor fostamatinib has activity in diffuse large B-cell lymphoma and chronic lymphocytic leukemia, and the PKC-β inhibitor enzastaurin is being used as consolidation therapy after remission in diffuse large B-cell lymphoma. This review discusses the biology behind the development of each new agent and the results of initial clinical trials. The goal is to provide the hematologist/oncologist background information on these new agents and understand their current and potential role in the management of patients.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalHematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
Volume2010
StatePublished - 2010

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Signal Transduction
Lymphoma
Protein Kinase C beta
Phosphatidylinositol 3-Kinase
Therapeutics
Tumor Microenvironment
Lymphoma, Large B-Cell, Diffuse
B-Cell Chronic Lymphocytic Leukemia
Sirolimus
Growth
B-Lymphocytes
Clinical Trials
Lymphocytes
Survival
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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