Radio carbon dioxide was detected in expired air of vitamin D-deficient chicks administered either 25-hydroxy-[26,27-14C]vitamin D3 or 1,25-dihydroxy-[26,27-14C]vitamin D3 intravenously. At 48 hours the amounts were 5.13 ± 1.02% and 11.8 ± 3.10% of the administered dose, respectively. This phenomenon, similar to the one observed in rats, represents side chain oxidation and elimination of either one or both of the 26 and 27 carbons from the viamin D molecule. The observation that the rate of 14CO2 evolution is maximal 4 hours after a dose of 1,25-dihydroxy-[26,27-14C]vitamin D3 suggests that this pathway may be of importance to the function of 1,25-dihydroxyvitamin D3.
|Original language||English (US)|
|Number of pages||4|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Mar 8 1976|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology