Siblings with ETV6/RUNX1-positive B-lymphoblastic leukemia: A single site experience and review of the literature

Daniel S. Martig, Cynthia M. Williamson, Xinjie Xu, William R. Sukov, Patricia T. Greipp, Nicole L. Hoppman, Linda B. Baughn, Rhett P. Ketterling, Jess F. Peterson

Research output: Contribution to journalArticle

Abstract

Siblings diagnosed with B-lymphoblastic leukemia (B-ALL) that share the same driver abnormality have been rarely described in the literature. Herein, we report three pairs of siblings (one non-identical pair, one maternal half-sibling pair, and one identical pair) all diagnosed with ETV6/RUNX1-positive B-ALL. Considering that ETV6/RUNX1 fusion is thought to represent a prenatal event and necessitates additional genomic alterations to result in leukemia, siblings of patient's with known ETV6/RUNX1-positive B-ALL may be at increased risk of ETV6/RUNX1-positive B-ALL due to common exposures (environmental or infectious) or shared germline polymorphisms.

Original languageEnglish (US)
Article number151588
JournalAnnals of Diagnostic Pathology
Volume48
DOIs
StatePublished - Oct 2020

Keywords

  • B-lymphoblastic leukemia (B-ALL)
  • ETV6/RUNX1 fusion
  • Siblings

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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