Siblings with ETV6/RUNX1-positive B-lymphoblastic leukemia: A single site experience and review of the literature

Daniel S. Martig; Cynthia M. Williamson; Xinjie Xu; William R. Sukov; Patricia T. Greipp; Nicole L. Hoppman; Linda B. Baughn; Rhett P. Ketterling; Jess F. Peterson

doi:10.1016/j.anndiagpath.2020.151588

Siblings with ETV6/RUNX1-positive B-lymphoblastic leukemia: A single site experience and review of the literature

Daniel S. Martig, Cynthia M. Williamson, Xinjie Xu, William R. Sukov, Patricia T. Greipp, Nicole L. Hoppman, Linda B. Baughn, Rhett P. Ketterling, Jess F. Peterson

Research output: Contribution to journal › Article › peer-review

Abstract

Siblings diagnosed with B-lymphoblastic leukemia (B-ALL) that share the same driver abnormality have been rarely described in the literature. Herein, we report three pairs of siblings (one non-identical pair, one maternal half-sibling pair, and one identical pair) all diagnosed with ETV6/RUNX1-positive B-ALL. Considering that ETV6/RUNX1 fusion is thought to represent a prenatal event and necessitates additional genomic alterations to result in leukemia, siblings of patient's with known ETV6/RUNX1-positive B-ALL may be at increased risk of ETV6/RUNX1-positive B-ALL due to common exposures (environmental or infectious) or shared germline polymorphisms.

Original language	English (US)
Article number	151588
Journal	Annals of Diagnostic Pathology
Volume	48
DOIs	https://doi.org/10.1016/j.anndiagpath.2020.151588
State	Published - Oct 2020

Keywords

B-lymphoblastic leukemia (B-ALL)
ETV6/RUNX1 fusion
Siblings

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.anndiagpath.2020.151588

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@article{69d05dcbcc2e4953964e02cf0879ab7d,

title = "Siblings with ETV6/RUNX1-positive B-lymphoblastic leukemia: A single site experience and review of the literature",

abstract = "Siblings diagnosed with B-lymphoblastic leukemia (B-ALL) that share the same driver abnormality have been rarely described in the literature. Herein, we report three pairs of siblings (one non-identical pair, one maternal half-sibling pair, and one identical pair) all diagnosed with ETV6/RUNX1-positive B-ALL. Considering that ETV6/RUNX1 fusion is thought to represent a prenatal event and necessitates additional genomic alterations to result in leukemia, siblings of patient's with known ETV6/RUNX1-positive B-ALL may be at increased risk of ETV6/RUNX1-positive B-ALL due to common exposures (environmental or infectious) or shared germline polymorphisms.",

keywords = "B-lymphoblastic leukemia (B-ALL), ETV6/RUNX1 fusion, Siblings",

author = "Martig, {Daniel S.} and Williamson, {Cynthia M.} and Xinjie Xu and Sukov, {William R.} and Greipp, {Patricia T.} and Hoppman, {Nicole L.} and Baughn, {Linda B.} and Ketterling, {Rhett P.} and Peterson, {Jess F.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = oct,

doi = "10.1016/j.anndiagpath.2020.151588",

language = "English (US)",

volume = "48",

journal = "Annals of Diagnostic Pathology",

issn = "1092-9134",

publisher = "W.B. Saunders Ltd",

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T2 - A single site experience and review of the literature

AU - Martig, Daniel S.

AU - Williamson, Cynthia M.

AU - Xu, Xinjie

AU - Sukov, William R.

AU - Greipp, Patricia T.

AU - Hoppman, Nicole L.

AU - Baughn, Linda B.

AU - Ketterling, Rhett P.

AU - Peterson, Jess F.

PY - 2020/10

Y1 - 2020/10

N2 - Siblings diagnosed with B-lymphoblastic leukemia (B-ALL) that share the same driver abnormality have been rarely described in the literature. Herein, we report three pairs of siblings (one non-identical pair, one maternal half-sibling pair, and one identical pair) all diagnosed with ETV6/RUNX1-positive B-ALL. Considering that ETV6/RUNX1 fusion is thought to represent a prenatal event and necessitates additional genomic alterations to result in leukemia, siblings of patient's with known ETV6/RUNX1-positive B-ALL may be at increased risk of ETV6/RUNX1-positive B-ALL due to common exposures (environmental or infectious) or shared germline polymorphisms.

AB - Siblings diagnosed with B-lymphoblastic leukemia (B-ALL) that share the same driver abnormality have been rarely described in the literature. Herein, we report three pairs of siblings (one non-identical pair, one maternal half-sibling pair, and one identical pair) all diagnosed with ETV6/RUNX1-positive B-ALL. Considering that ETV6/RUNX1 fusion is thought to represent a prenatal event and necessitates additional genomic alterations to result in leukemia, siblings of patient's with known ETV6/RUNX1-positive B-ALL may be at increased risk of ETV6/RUNX1-positive B-ALL due to common exposures (environmental or infectious) or shared germline polymorphisms.

KW - B-lymphoblastic leukemia (B-ALL)

KW - ETV6/RUNX1 fusion

KW - Siblings

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JO - Annals of Diagnostic Pathology

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ER -

Siblings with ETV6/RUNX1-positive B-lymphoblastic leukemia: A single site experience and review of the literature

Abstract

Keywords

ASJC Scopus subject areas

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