Abstract
Background Cardiac resynchronization therapy (CRT) is considered as a standard adjunct therapy in symptomatic patients with congestive heart failure (CHF) who have a prolonged QRS. There is an increasing number of patients who do not receive de novo CRT devices but are upgraded from right ventricular (RV) pacing to biventricular stimulation. We wanted to evaluate the benefit of CRT in patients with chronic RV pacing in comparison to previously non-paced heart failure patients. Methods One hundred and sixty-five patients who had their device newly implanted (group I) and 116 who were upgraded from previously implanted RV pacing systems (group II) at Mayo Clinic Hospital were retrospectively analyzed. Clinical and echocardiographic response to CRT was evaluated. Mean follow-up time was 290 ± 250 days. Results Baseline characteristics did not differ between the two groups of patients. Clinical response rate was identical in Groups I and II (65 vs. 65%, respectively; P = 0.98) and echocardiographic response rate was similar in both groups of patients (64 vs. 62%; P = 0.80). Post-implant QRS increased in group I and was reduced in group II (5 (27.4) vs. - 20.0 (33.9) ms; P < 0.001). NYHA class improvement (- 0.7 (0.6) vs. - 0.7 (0.6), P = 0.81), LV ejection fraction increase (9.2 (12.9) vs. 8.2 (9.9)%; P = 0.55) and LV end-systolic volume reduction (- 34.5 (50.7) vs. - 25.7 (47.4)%; P = 0.28) were comparable in both groups. Conclusions Chronically RV-paced patients who receive CRT have similar short-term benefits when compared with patients with new CRT implantations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 195-199 |
| Number of pages | 5 |
| Journal | International Journal of Cardiology |
| Volume | 219 |
| DOIs | |
| State | Published - Sep 15 2016 |
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Keywords
- Cardiac resynchronization therapy
- Heart failure
- Right ventricular pacing
- Upgrading
ASJC Scopus subject areas
- Medicine(all)
- Cardiology and Cardiovascular Medicine
Cite this
Short-term outcome of cardiac resynchronization therapy - A comparison between newly implanted and chronically right ventricle-paced patients. / Lipar, Luka; Srivathsan, Komandoor; Scott, Luis.
In: International Journal of Cardiology, Vol. 219, 15.09.2016, p. 195-199.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Short-term outcome of cardiac resynchronization therapy - A comparison between newly implanted and chronically right ventricle-paced patients
AU - Lipar, Luka
AU - Srivathsan, Komandoor
AU - Scott, Luis
PY - 2016/9/15
Y1 - 2016/9/15
N2 - Background Cardiac resynchronization therapy (CRT) is considered as a standard adjunct therapy in symptomatic patients with congestive heart failure (CHF) who have a prolonged QRS. There is an increasing number of patients who do not receive de novo CRT devices but are upgraded from right ventricular (RV) pacing to biventricular stimulation. We wanted to evaluate the benefit of CRT in patients with chronic RV pacing in comparison to previously non-paced heart failure patients. Methods One hundred and sixty-five patients who had their device newly implanted (group I) and 116 who were upgraded from previously implanted RV pacing systems (group II) at Mayo Clinic Hospital were retrospectively analyzed. Clinical and echocardiographic response to CRT was evaluated. Mean follow-up time was 290 ± 250 days. Results Baseline characteristics did not differ between the two groups of patients. Clinical response rate was identical in Groups I and II (65 vs. 65%, respectively; P = 0.98) and echocardiographic response rate was similar in both groups of patients (64 vs. 62%; P = 0.80). Post-implant QRS increased in group I and was reduced in group II (5 (27.4) vs. - 20.0 (33.9) ms; P < 0.001). NYHA class improvement (- 0.7 (0.6) vs. - 0.7 (0.6), P = 0.81), LV ejection fraction increase (9.2 (12.9) vs. 8.2 (9.9)%; P = 0.55) and LV end-systolic volume reduction (- 34.5 (50.7) vs. - 25.7 (47.4)%; P = 0.28) were comparable in both groups. Conclusions Chronically RV-paced patients who receive CRT have similar short-term benefits when compared with patients with new CRT implantations.
AB - Background Cardiac resynchronization therapy (CRT) is considered as a standard adjunct therapy in symptomatic patients with congestive heart failure (CHF) who have a prolonged QRS. There is an increasing number of patients who do not receive de novo CRT devices but are upgraded from right ventricular (RV) pacing to biventricular stimulation. We wanted to evaluate the benefit of CRT in patients with chronic RV pacing in comparison to previously non-paced heart failure patients. Methods One hundred and sixty-five patients who had their device newly implanted (group I) and 116 who were upgraded from previously implanted RV pacing systems (group II) at Mayo Clinic Hospital were retrospectively analyzed. Clinical and echocardiographic response to CRT was evaluated. Mean follow-up time was 290 ± 250 days. Results Baseline characteristics did not differ between the two groups of patients. Clinical response rate was identical in Groups I and II (65 vs. 65%, respectively; P = 0.98) and echocardiographic response rate was similar in both groups of patients (64 vs. 62%; P = 0.80). Post-implant QRS increased in group I and was reduced in group II (5 (27.4) vs. - 20.0 (33.9) ms; P < 0.001). NYHA class improvement (- 0.7 (0.6) vs. - 0.7 (0.6), P = 0.81), LV ejection fraction increase (9.2 (12.9) vs. 8.2 (9.9)%; P = 0.55) and LV end-systolic volume reduction (- 34.5 (50.7) vs. - 25.7 (47.4)%; P = 0.28) were comparable in both groups. Conclusions Chronically RV-paced patients who receive CRT have similar short-term benefits when compared with patients with new CRT implantations.
KW - Cardiac resynchronization therapy
KW - Heart failure
KW - Right ventricular pacing
KW - Upgrading
UR - http://www.scopus.com/inward/record.url?scp=84975261138&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975261138&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2016.06.054
DO - 10.1016/j.ijcard.2016.06.054
M3 - Article
C2 - 27327506
AN - SCOPUS:84975261138
VL - 219
SP - 195
EP - 199
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -