Short-term mortality after a first episode of status epilepticus

Giancarlo Logroscino, Dale C. Hesdorffer, Gregory Cascino, John F. Annegers, W. Allen Hauser

Research output: Contribution to journalArticlepeer-review

250 Scopus citations

Abstract

Purpose: Studies evaluating short-term mortality among people who experience status epilepticus (SE) have produced conflicting results. Most studies are derived from clinical series with results affected by unspecified follow-up period and select referral of cases. This study was planned to evaluate short-term mortality after a first episode of SE. Methods: We performed a population-based retrospective cohort study to determine the short-term mortality following a first episode of SE. Between January 1, 1965 and December 31, 1984, we studied all first episodes of afebrile SE who received medical attention in Rochester, Minnesota. Cases were followed until death or end of the study (February 1996). Results: Mortality within the first 30 days was 19% (38 deaths out of 201 incident SE). Thirty-four deaths (89%) occurred among those with nonfebrile acute symptomatic SE, while 4 deaths (11%) occurred among those with unprovoked SE. Within the acute symptomatic group, after adjusting for age, there was a decreased risk of death in women (RR = 0.4; 95% CI: 0.2-0.9). No effect of duration or seizure type was shown after adjusting for other risk factors. Conclusions: One out of 5 subjects with SE died within the fast 30 days. Short-term mortality is associated with the presence of an underlying acute etiology. Among acute symptomatic cases, women had a decreased risk of dying.

Original languageEnglish (US)
Pages (from-to)1344-1349
Number of pages6
JournalEpilepsia
Volume38
Issue number12
DOIs
StatePublished - Dec 1997

Keywords

  • Epidemiology
  • Epilepsy
  • Mortality
  • Prognosis
  • Status epilepticus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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