TY - JOUR
T1 - Short-Term and Long-Term Outcomes for Patients with Autoimmune Pancreatitis After Pancreatectomy
T2 - A Multi-institutional Study
AU - Clark, Clancy J.
AU - Morales-Oyarvide, Vicente
AU - Zaydfudim, Victor
AU - Stauffer, John
AU - Deshpande, Vikram
AU - Smyrk, Thomas C.
AU - Chari, Suresh T.
AU - Fernández-del Castillo, Carlos
AU - Farnell, Michael B.
N1 - Funding Information:
Acknowledgments Funding for this study was provided by the Mayo Clinic.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2013/5
Y1 - 2013/5
N2 - Background: Autoimmune pancreatitis (AIP) is a rare subtype of chronic pancreatitis that may mimic adenocarcinoma of the pancreas. The aim of this study was to evaluate the short-term and long-term outcomes of pancreatectomy for patients with AIP. Methods: In this multi-institutional study, we identified all patients who underwent pancreatectomy for AIP from 1986 to 2011. AIP was confirmed by pathology review. Clinical presentation, operative details, and postoperative outcomes were analyzed. Results: Seventy-four patients (median age, 60 years; 69 % male) with AIP underwent pancreatectomy. The main indication for operation was concern for malignancy (n = 59, 80 %). No patients were found to have pancreatic adenocarcinoma on final pathology. Major complications occurred in ten (14 %) patients, with one perioperative death (1 %). Clinically relevant (grade B/C) pancreatic fistulae occurred in two patients. No patients required reoperation for AIP and 11 (17 %) patients developed recurrent AIP. Conclusion: Although we do not advocate pancreatectomy for AIP, strong suspicion of malignancy may require an operation in selected patients. For patients with AIP, pancreatectomy resulted in few pancreatic fistulae, a low rate of re-intervention, and a 17 % recurrence rate.
AB - Background: Autoimmune pancreatitis (AIP) is a rare subtype of chronic pancreatitis that may mimic adenocarcinoma of the pancreas. The aim of this study was to evaluate the short-term and long-term outcomes of pancreatectomy for patients with AIP. Methods: In this multi-institutional study, we identified all patients who underwent pancreatectomy for AIP from 1986 to 2011. AIP was confirmed by pathology review. Clinical presentation, operative details, and postoperative outcomes were analyzed. Results: Seventy-four patients (median age, 60 years; 69 % male) with AIP underwent pancreatectomy. The main indication for operation was concern for malignancy (n = 59, 80 %). No patients were found to have pancreatic adenocarcinoma on final pathology. Major complications occurred in ten (14 %) patients, with one perioperative death (1 %). Clinically relevant (grade B/C) pancreatic fistulae occurred in two patients. No patients required reoperation for AIP and 11 (17 %) patients developed recurrent AIP. Conclusion: Although we do not advocate pancreatectomy for AIP, strong suspicion of malignancy may require an operation in selected patients. For patients with AIP, pancreatectomy resulted in few pancreatic fistulae, a low rate of re-intervention, and a 17 % recurrence rate.
KW - Adult
KW - Autoimmune pancreatitis
KW - Chronic pancreatitis
KW - IgG4
KW - Outcomes
KW - Pancreatectomy
KW - Surgery
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84876111237&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876111237&partnerID=8YFLogxK
U2 - 10.1007/s11605-013-2145-1
DO - 10.1007/s11605-013-2145-1
M3 - Review article
C2 - 23319396
AN - SCOPUS:84876111237
SN - 1091-255X
VL - 17
SP - 899
EP - 906
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
IS - 5
ER -