Abstract
We studied short-term (30 min) adaptation of the vestibulo-ocular reflex (VOR) in five normal humans using a "position error" stimulus without retinal image motion. Both before and after adaptation a velocity gain (peak slow-phase eye velocity/peak head velocity) and a position gain (total eye movement during chair rotation/amplitude of chair motion) were measured in darkness using search coils. The vestibular stimulus was a brief (∼700 ms), 15° chair rotation in darkness (peak velocity 43°/s). To elicit adaptation, a straight-ahead fixation target disappeared during chair movement and when the chair stopped the target reappeared at a new location in front of the subject for gain-decrease (x0) adaptation, or 10° opposite to chair motion for gain-increase (x1.67) adaptation. This position-error stimulus was effective at inducing VOR adaptation, though for gain-increase adaptation the primary strategy was to substitute augmenting saccades during rotation while for gain-decrease adaptation both corrective saccades and a decrease in slow-phase velocity occurred. Finally, the presence of the position-error signal alone, at the end of head rotation, without any attempt to fix upon it, was not sufficient to induce adaptation. Adaptation did occur, however, if the subject did make a saccade to the target after head rotation, or even if the subject paid attention to the new location of the target without actually looking at it.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 94-110 |
| Number of pages | 17 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1004 |
| DOIs | |
| State | Published - 2003 |
| Externally published | Yes |
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Keywords
- Adaptation
- Cognition
- Saccades
- Vestibulo-ocular reflex
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Short-term adaptation of the VOR : Non-retinal-slip error signals and saccade substitution. / Eggers, Scott Daniel; De Pennington, Nick; Walker, Mark F.; Shelhamer, Mark; Zee, David S.
In: Annals of the New York Academy of Sciences, Vol. 1004, 2003, p. 94-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Short-term adaptation of the VOR
T2 - Non-retinal-slip error signals and saccade substitution
AU - Eggers, Scott Daniel
AU - De Pennington, Nick
AU - Walker, Mark F.
AU - Shelhamer, Mark
AU - Zee, David S.
PY - 2003
Y1 - 2003
N2 - We studied short-term (30 min) adaptation of the vestibulo-ocular reflex (VOR) in five normal humans using a "position error" stimulus without retinal image motion. Both before and after adaptation a velocity gain (peak slow-phase eye velocity/peak head velocity) and a position gain (total eye movement during chair rotation/amplitude of chair motion) were measured in darkness using search coils. The vestibular stimulus was a brief (∼700 ms), 15° chair rotation in darkness (peak velocity 43°/s). To elicit adaptation, a straight-ahead fixation target disappeared during chair movement and when the chair stopped the target reappeared at a new location in front of the subject for gain-decrease (x0) adaptation, or 10° opposite to chair motion for gain-increase (x1.67) adaptation. This position-error stimulus was effective at inducing VOR adaptation, though for gain-increase adaptation the primary strategy was to substitute augmenting saccades during rotation while for gain-decrease adaptation both corrective saccades and a decrease in slow-phase velocity occurred. Finally, the presence of the position-error signal alone, at the end of head rotation, without any attempt to fix upon it, was not sufficient to induce adaptation. Adaptation did occur, however, if the subject did make a saccade to the target after head rotation, or even if the subject paid attention to the new location of the target without actually looking at it.
AB - We studied short-term (30 min) adaptation of the vestibulo-ocular reflex (VOR) in five normal humans using a "position error" stimulus without retinal image motion. Both before and after adaptation a velocity gain (peak slow-phase eye velocity/peak head velocity) and a position gain (total eye movement during chair rotation/amplitude of chair motion) were measured in darkness using search coils. The vestibular stimulus was a brief (∼700 ms), 15° chair rotation in darkness (peak velocity 43°/s). To elicit adaptation, a straight-ahead fixation target disappeared during chair movement and when the chair stopped the target reappeared at a new location in front of the subject for gain-decrease (x0) adaptation, or 10° opposite to chair motion for gain-increase (x1.67) adaptation. This position-error stimulus was effective at inducing VOR adaptation, though for gain-increase adaptation the primary strategy was to substitute augmenting saccades during rotation while for gain-decrease adaptation both corrective saccades and a decrease in slow-phase velocity occurred. Finally, the presence of the position-error signal alone, at the end of head rotation, without any attempt to fix upon it, was not sufficient to induce adaptation. Adaptation did occur, however, if the subject did make a saccade to the target after head rotation, or even if the subject paid attention to the new location of the target without actually looking at it.
KW - Adaptation
KW - Cognition
KW - Saccades
KW - Vestibulo-ocular reflex
UR - http://www.scopus.com/inward/record.url?scp=1942470534&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1942470534&partnerID=8YFLogxK
U2 - 10.1196/annals.1303.010
DO - 10.1196/annals.1303.010
M3 - Article
C2 - 14662451
AN - SCOPUS:1942470534
VL - 1004
SP - 94
EP - 110
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -