Short-course radiotherapy is not optimal for spinal cord compression due to myeloma

Dirk Rades, Peter J. Hoskin, Lukas J.A. Stalpers, Rainer Schulte, Philip Poortmans, Theo Veninga, Jochen Dahm-Daphi, Nermina Obralic, Ingeborg Wildfang, Roja Bahrehmand, Rita Engenhart-Cabilic, Steven E. Schild

Research output: Contribution to journalArticle

39 Scopus citations


Purpose: To investigate the suitability of short-course radiotherapy (RT) for spinal cord compression (SCC) in myeloma patients. Methods and Materials: Data for 172 myeloma patients irradiated between January 1994 and December 2004 for SCC were retrospectively evaluated. Short-course RT (1 × 8 Gy, 5 × 4 Gy, n = 61) and long-course RT (10 × 3 Gy, 15 × 2.5 Gy, 20 × 2 Gy, n = 111) were compared for functional outcome up to 24 months after RT. In addition, 10 potential prognostic factors were investigated. Results: Improvement of motor function occurred in 90 patients (52%). Forty-seven percent of nonambulatory patients regained the ability to walk. Functional outcome was significantly influenced by the time of developing motor deficits before RT. Improvement of motor function was more frequent after long-course RT than after short-course RT: 59% vs. 39% (p = 0.10) at 1 month, 67% vs. 43% (p = 0.043) at 6 months, 76% vs. 40% (p = 0.003) at 12 months, 78% vs. 43% (p = 0.07) at 18 months, and 83% v 54% (p = 0.33) at 24 months. A subgroup analysis of the long-course RT group demonstrated a similar functional outcome for 10 × 3 Gy when compared with 15 × 2.5 Gy and 20 × 2 Gy. Conclusions: Long-course RT is preferable for SCC in myeloma patients because it resulted in better functional outcome than short-course RT. Treatment with 10 × 3 Gy can be considered appropriate.

Original languageEnglish (US)
Pages (from-to)1452-1457
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number5
StatePublished - Apr 1 2006


  • Myeloma
  • Radiotherapy
  • Spinal cord compression

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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    Rades, D., Hoskin, P. J., Stalpers, L. J. A., Schulte, R., Poortmans, P., Veninga, T., Dahm-Daphi, J., Obralic, N., Wildfang, I., Bahrehmand, R., Engenhart-Cabilic, R., & Schild, S. E. (2006). Short-course radiotherapy is not optimal for spinal cord compression due to myeloma. International Journal of Radiation Oncology Biology Physics, 64(5), 1452-1457.