Short-and long-term individual variation in cardiac troponin in patients with stable coronary artery disease

Anna M. Nordenskjöld, Håkan Ahlström, Kai M. Eggers, Ole Fröbert, Allan S. Jaffe, Per Venge, Bertil Lindahl

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

BACKGROUND: A rise or fall of cardiac troponin is a prerequisite for the diagnosis of acute myocardial infarction. Defining significant changes requires knowledge of both biological and analytical variation. The shortterm biological variation of cardiac troponin in healthy individuals is 3%-48%. However, healthy individuals may not be representative for patients in whom cardiac troponin measurement is often of clinical importance. Therefore, we studied the individual variation of cardiac troponin in patients with symptoms of stable coronary artery disease. METHODS: Twenty-four patients scheduled for elective coronary angiography were included. Blood samples were drawn once at enrollment and serially at six 4-h intervals on the day before coronary angiography. Cardiac troponin was measured with hs-cTn assays from Abbott Laboratories (premarket cTnI assay) and Roche Diagnostics (Elecsys® cTnT assay with two different lots). RESULTS: The short-term individual variation in cardiac troponin I (cTnI) was 14%, the reference change value (RCV) 49%, and RCV-log-normal (rise/fall) 54%/-35%. The corresponding values for cTnT were 7%, 23%, and 26%/-21%. The long-term variation for cTnI was 24%, RCV 69%, and RCV-log-normal (rise/ fall) 97%/-49%. The corresponding values for cTnT were 11%, 32%, and 37%/-27%. CONCLUSIONS: The short-term individual variation of cardiac troponin in patients with symptoms of stable coronary artery disease is similar to the biological variation previously demonstrated in healthy individuals. Our results suggest that a change in cardiac troponin concentrations of <50% can be used in attempting to diagnose acute myocardial injury. To detect significant long-term changes in cardiac troponin concentrations, larger changes will be required.

Original languageEnglish (US)
Pages (from-to)401-409
Number of pages9
JournalClinical chemistry
Volume59
Issue number2
DOIs
StatePublished - Feb 1 2013

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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