TY - JOUR
T1 - Shock wave lithotripsy and diabetes mellitus
T2 - A population-based cohort study
AU - De Cgin, Mitra
AU - Krambeck, Amy E.
AU - Rule, Andrew D.
AU - Li, Xujian
AU - Bergstralh, Eric J.
AU - Gettman, Matthew T.
AU - Lieske, John C.
N1 - Funding Information:
Funding Support: This study was supported by the National Institutes of Health through the Mayo Clinic O'Brien Urology Research Center (grant DK83007 ) and the Rochester Epidemiology Project (grant R01 AG034676 ).
PY - 2012/2
Y1 - 2012/2
N2 - Objective: To determine if shock wave lithotripsy (SWL) is associated with diabetes mellitus (DM) in a community setting. The pancreas is vulnerable to injury at SWL as evidenced by case studies; thus, concern exists for the development of DM after SWL. Methods: The Rochester Epidemiologic Project was used to identify all Olmsted County, Minnesota residents diagnosed with urolithiasis from 1985 to 2008. New-onset DM was identified by diagnostic codes and treatment with SWL by surgical codes. Cox proportional hazards models were used to determine the risk of DM after SWL therapy. Results: A total of 5287 incident cases of stone formation without pre-existing DM and with <3 months of follow-up. After an average follow-up of 8.7 years, 423 patients (8%) were treated with SWL and new-onset DM had developed in 743 (12%). The diagnosis of DM followed SWL in 77 patients. However, no association was evident between SWL and the development of DM before (hazard ratio 0.98, 95% confidence interval 0.76-1.26) or after (hazard ratio 0.92, 95% confidence interval 0.71-1.18) SWL, controlling for age, sex, and obesity. Conclusion: In the present large, population-based cohort, the long-term risk of developing DM was not increased in persons who underwent SWL to treat their kidney stones.
AB - Objective: To determine if shock wave lithotripsy (SWL) is associated with diabetes mellitus (DM) in a community setting. The pancreas is vulnerable to injury at SWL as evidenced by case studies; thus, concern exists for the development of DM after SWL. Methods: The Rochester Epidemiologic Project was used to identify all Olmsted County, Minnesota residents diagnosed with urolithiasis from 1985 to 2008. New-onset DM was identified by diagnostic codes and treatment with SWL by surgical codes. Cox proportional hazards models were used to determine the risk of DM after SWL therapy. Results: A total of 5287 incident cases of stone formation without pre-existing DM and with <3 months of follow-up. After an average follow-up of 8.7 years, 423 patients (8%) were treated with SWL and new-onset DM had developed in 743 (12%). The diagnosis of DM followed SWL in 77 patients. However, no association was evident between SWL and the development of DM before (hazard ratio 0.98, 95% confidence interval 0.76-1.26) or after (hazard ratio 0.92, 95% confidence interval 0.71-1.18) SWL, controlling for age, sex, and obesity. Conclusion: In the present large, population-based cohort, the long-term risk of developing DM was not increased in persons who underwent SWL to treat their kidney stones.
UR - http://www.scopus.com/inward/record.url?scp=84856741431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856741431&partnerID=8YFLogxK
U2 - 10.1016/j.urology.2011.07.1430
DO - 10.1016/j.urology.2011.07.1430
M3 - Article
C2 - 22088569
AN - SCOPUS:84856741431
SN - 0090-4295
VL - 79
SP - 298
EP - 302
JO - Urology
JF - Urology
IS - 2
ER -