Shining a light on posterior cortical atrophy

Sebastian J. Crutch, Jonathan M. Schott, Gil D. Rabinovici, Bradley F. Boeve, Stefano F. Cappa, Bradford C. Dickerson, Bruno Dubois, Neill R. Graff-Radford, Pierre Krolak-Salmon, Manja Lehmann, Mario F. Mendez, Yolande Pijnenburg, Natalie S. Ryan, Philip Scheltens, Tim Shakespeare, David F. Tang-Wai, Wiesje M. Van Der Flier, Lisa Bain, Maria C. Carrillo, Nick C. Fox

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Posterior cortical atrophy (PCA) is a clinicoradiologic syndrome characterized by progressive decline in visual processing skills, relatively intact memory and language in the early stages, and atrophy of posterior brain regions. Misdiagnosis of PCA is common, owing not only to its relative rarity and unusual and variable presentation, but also because patients frequently first seek the opinion of an ophthalmologist, who may note normal eye examinations by their usual tests but may not appreciate cortical brain dysfunction. Seeking to raise awareness of the disease, stimulate research, and promote collaboration, a multidisciplinary group of PCA research clinicians formed an international working party, which had its first face-to-face meeting on July 13, 2012 in Vancouver, Canada, prior to the Alzheimer's Association International Conference.

Original languageEnglish (US)
Pages (from-to)463-465
Number of pages3
JournalAlzheimer's and Dementia
Volume9
Issue number4
DOIs
StatePublished - Jul 2013

Keywords

  • Alzheimer's dementia
  • Atypical dementia
  • Diagnostic criteria
  • Differential diagnosis
  • Posterior cortical atrophy
  • Simultanagnosia
  • Visual disturbances
  • Visualperceptual disturbances

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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  • Cite this

    Crutch, S. J., Schott, J. M., Rabinovici, G. D., Boeve, B. F., Cappa, S. F., Dickerson, B. C., Dubois, B., Graff-Radford, N. R., Krolak-Salmon, P., Lehmann, M., Mendez, M. F., Pijnenburg, Y., Ryan, N. S., Scheltens, P., Shakespeare, T., Tang-Wai, D. F., Van Der Flier, W. M., Bain, L., Carrillo, M. C., & Fox, N. C. (2013). Shining a light on posterior cortical atrophy. Alzheimer's and Dementia, 9(4), 463-465. https://doi.org/10.1016/j.jalz.2012.11.004