Shear wave elastography plaque characterization with mechanical testing validation

A phantom study

E. Widman, E. Maksuti, D. Larsson, Matthew W Urban, A. Bjällmark, M. Larsson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Determining plaque vulnerability is critical when selecting the most suitable treatment for patients with atherosclerotic plaque. Currently, clinical non-invasive ultrasound-based methods for plaque characterization are limited to visual assessment of plaque morphology and new quantitative methods are needed. In this study, shear wave elastography (SWE) was used to characterize hard and soft plaque mimicking inclusions in six common carotid artery phantoms by using phase velocity analysis in static and dynamic environments. The results were validated with mechanical tensile testing. In the static environment, SWE measured a mean shear modulus of 5.8 ± 0.3 kPa and 106.2 ± 17.2 kPa versus 3.3 ± 0.5 kPa and 98.3 ± 3.4 kPa measured by mechanical testing in the soft and hard plaques respectively. Furthermore, it was possible to measure the plaques' shear moduli throughout a simulated cardiac cycle. The results show good agreement between SWE and mechanical testing and indicate the possibility for in vivo arterial plaque characterization using SWE.

Original languageEnglish (US)
Article number3151
Pages (from-to)3151-3174
Number of pages24
JournalPhysics in Medicine and Biology
Volume60
Issue number8
DOIs
StatePublished - Apr 21 2015

Fingerprint

Elasticity Imaging Techniques
Common Carotid Artery
Atherosclerotic Plaques

Keywords

  • atherosclerosis
  • carotid artery
  • mechanical testing
  • phantom
  • plaque characterization
  • shear wave elastography
  • ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Shear wave elastography plaque characterization with mechanical testing validation : A phantom study. / Widman, E.; Maksuti, E.; Larsson, D.; Urban, Matthew W; Bjällmark, A.; Larsson, M.

In: Physics in Medicine and Biology, Vol. 60, No. 8, 3151, 21.04.2015, p. 3151-3174.

Research output: Contribution to journalArticle

Widman, E. ; Maksuti, E. ; Larsson, D. ; Urban, Matthew W ; Bjällmark, A. ; Larsson, M. / Shear wave elastography plaque characterization with mechanical testing validation : A phantom study. In: Physics in Medicine and Biology. 2015 ; Vol. 60, No. 8. pp. 3151-3174.
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