Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism

Nima Tajbakhsh, Wenzhe Xue, Hong Wu, Jianming Liang, Eileen M. McMahon, Marek Belohlavek

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Acute pulmonary embolism (APE) is known as one of the major causes of sudden death. However, high level of mortality caused by APE can be reduced, if detected in early stages of development. Hence, biomarkers capable of early detection of APE are of utmost importance. This study investigates how APE affects the biomechanics of the cardiac right ventricle (RV), taking one step towards developing functional biomarkers for early diagnosis and determination of prognosis of APE. To that end, we conducted a pilot study in pigs, which revealed the following major changes due to the severe RV afterload caused by APE: (1) waving paradoxical motion of the RV inner boundary, (2) decrease in local curvature of the septum, (3) lower positive correlation between the movement of inner boundaries of the septal and free walls of the RV, (4) slower blood ejection by the RV, and (5) discontinuous movement observed particularly in the middle of the RV septal wall.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8317
DOIs
StatePublished - 2012
EventMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, CA, United States
Duration: Feb 5 2012Feb 7 2012

Other

OtherMedical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego, CA
Period2/5/122/7/12

Fingerprint

embolisms
Right Ventricular Dysfunction
Biomarkers
Pulmonary Embolism
Heart Ventricles
Biomechanics
Blood
biomarkers
cardiac ventricles
biodynamics
septum
swine
prognosis
mortality
death
ejection
blood
Sudden Death
Biomechanical Phenomena
curvature

Keywords

  • Acute pulmonary embolism
  • Right ventricle
  • Shape-based analysis

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Tajbakhsh, N., Xue, W., Wu, H., Liang, J., McMahon, E. M., & Belohlavek, M. (2012). Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8317). [83170G] https://doi.org/10.1117/12.913299

Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism. / Tajbakhsh, Nima; Xue, Wenzhe; Wu, Hong; Liang, Jianming; McMahon, Eileen M.; Belohlavek, Marek.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8317 2012. 83170G.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tajbakhsh, N, Xue, W, Wu, H, Liang, J, McMahon, EM & Belohlavek, M 2012, Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8317, 83170G, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, CA, United States, 2/5/12. https://doi.org/10.1117/12.913299
Tajbakhsh N, Xue W, Wu H, Liang J, McMahon EM, Belohlavek M. Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8317. 2012. 83170G https://doi.org/10.1117/12.913299
Tajbakhsh, Nima ; Xue, Wenzhe ; Wu, Hong ; Liang, Jianming ; McMahon, Eileen M. ; Belohlavek, Marek. / Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8317 2012.
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