SH2-Containing inositol 5′-phosphatase inhibits transformation of abelson murine leukemia virus

Shawn P. Fessler, Naomi Rosenberg, Linda Baughn

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Abstract

v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) transforms pre-B cells. Transformation requires the phosphatidylinositol 3-kinase (PI3K) pathway. This pathway is antagonized by SH2-containing inositol 5′-phosphatase (SHIP), raising the possibility that v-Abl modulates PI3K signaling through SHIP. Consistent with this, we show that v-Abl expression reduces levels of full-length p145 SHIP in a v-Abl kinase activity-dependent fashion. This event requires signals from the Abl SH2 domain but not the carboxyl terminus. Forced expression of full-length SHIP significantly reduces Ab-MLV pre-B-cell transformation. Therefore, reduction of SHIP protein by v-Abl is a critical component in Ab-MLV transformation.

Original languageEnglish (US)
Pages (from-to)9239-9242
Number of pages4
JournalJournal of Virology
Volume85
Issue number17
DOIs
StatePublished - Sep 1 2011
Externally publishedYes

Fingerprint

Abelson murine leukemia virus
Murine leukemia virus
Oncogene Proteins v-abl
Phosphatidylinositol 3-Kinase
B-Lymphoid Precursor Cells
phosphatidylinositol 3-kinase
B-lymphocytes
protein-tyrosine kinases
src Homology Domains
Protein-Tyrosine Kinases
phosphotransferases (kinases)
Phosphotransferases
Inositol Polyphosphate 5-Phosphatases
inositols

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

SH2-Containing inositol 5′-phosphatase inhibits transformation of abelson murine leukemia virus. / Fessler, Shawn P.; Rosenberg, Naomi; Baughn, Linda.

In: Journal of Virology, Vol. 85, No. 17, 01.09.2011, p. 9239-9242.

Research output: Contribution to journalComment/debate

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