SH2-Containing inositol 5′-phosphatase inhibits transformation of abelson murine leukemia virus

Shawn P. Fessler, Naomi Rosenberg, Linda B. Baughn

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations

Abstract

v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) transforms pre-B cells. Transformation requires the phosphatidylinositol 3-kinase (PI3K) pathway. This pathway is antagonized by SH2-containing inositol 5′-phosphatase (SHIP), raising the possibility that v-Abl modulates PI3K signaling through SHIP. Consistent with this, we show that v-Abl expression reduces levels of full-length p145 SHIP in a v-Abl kinase activity-dependent fashion. This event requires signals from the Abl SH2 domain but not the carboxyl terminus. Forced expression of full-length SHIP significantly reduces Ab-MLV pre-B-cell transformation. Therefore, reduction of SHIP protein by v-Abl is a critical component in Ab-MLV transformation.

Original languageEnglish (US)
Pages (from-to)9239-9242
Number of pages4
JournalJournal of virology
Volume85
Issue number17
DOIs
StatePublished - Sep 2011

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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