sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice

Chang Hoon Cho, Ki Hyun Yoo, Alfredo Oliveros, Summer Paulson, Syed Mohammed Qasim Hussaini, Jan Van Deursen, Mi-Hyeon D Jang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Wnt signaling is a well-known molecular pathway in age-related pathogenesis and therapy of disease. While prior studies have mainly focused on Wnt ligands or Wnt activators, the in vivo functions of naturally secreted Wnt inhibitors are not clear, especially in brain aging. Using BubR1H/H mice as a novel mouse model of accelerated aging, we report that genetic inhibition of sFRP3 restores the reduced body and brain size observed in BubR1H/H mice. Furthermore, sFRP3 inhibition ameliorates hypomyelination in the corpus callosum and rescues neural progenitor proliferation in the hippocampal dentate gyrus of BubR1H/H mice. Taken together, our study identifies sFRP3 as a new molecular factor that cooperates with BubR1 function to regulate brain development, myelination, and hippocampal neurogenesis.

Original languageEnglish (US)
Article numbere12899
JournalAging Cell
DOIs
StateAccepted/In press - Jan 1 2019

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Brain
Parahippocampal Gyrus
Corpus Callosum
Neurogenesis
Dentate Gyrus
Body Size
Ligands
Therapeutics

Keywords

  • BubR1
  • myelination
  • neurogenesis
  • progeria
  • sFRP3

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Cite this

Cho, C. H., Yoo, K. H., Oliveros, A., Paulson, S., Hussaini, S. M. Q., Van Deursen, J., & Jang, M-H. D. (Accepted/In press). sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice. Aging Cell, [e12899]. https://doi.org/10.1111/acel.12899

sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice. / Cho, Chang Hoon; Yoo, Ki Hyun; Oliveros, Alfredo; Paulson, Summer; Hussaini, Syed Mohammed Qasim; Van Deursen, Jan; Jang, Mi-Hyeon D.

In: Aging Cell, 01.01.2019.

Research output: Contribution to journalArticle

Cho, Chang Hoon ; Yoo, Ki Hyun ; Oliveros, Alfredo ; Paulson, Summer ; Hussaini, Syed Mohammed Qasim ; Van Deursen, Jan ; Jang, Mi-Hyeon D. / sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice. In: Aging Cell. 2019.
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