Sex steroids and the pathogenesis of osteoporosis

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Significant bone loss occurs with aging in both men and women, leading to alterations in skeletal microarchitecture and increased fracture incidence. This chapter expresses that sex steroids play in the development and progression of osteoporosis in both men and women. Estrogen plays a central role in osteoblast biology, where it promotes bone marrow stromal cell differentiation toward the osteoblast lineage, increases preosteoblast to osteoblast differentiation, and limits both osteoblast and osteocyte apoptosis. Estrogen also has other important effects on suppressing bone resorption. Relative to postmenopausal women, elderly men on average lose one-half as much bone and sustain one-third as many fragility fractures. In addition to the effects of sex steroids, it is important to recognize that nonsex hormonal changes also occur with aging in both men and women. These include reductions in the production of growth factors important for osteoblast differentiation and function.

Original languageEnglish (US)
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Publisherwiley
Pages412-418
Number of pages7
ISBN (Electronic)9781119266594
ISBN (Print)9781119266563
DOIs
StatePublished - Jan 1 2018

Keywords

  • Aging
  • Estrogen
  • Fragility fractures
  • Nonsex hormonal changes
  • Osteoblast lineage
  • Osteoporosis
  • Sex steroids
  • Skeletal microarchitecture

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Drake, M. M., & Khosla, S. (2018). Sex steroids and the pathogenesis of osteoporosis. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (pp. 412-418). wiley. https://doi.org/10.1002/9781119266594.ch52