TY - JOUR
T1 - Sex steroids and endothelial function
T2 - translating basic science to clinical practice
AU - Miller, Virginia M.
AU - Mulvagh, Sharon L.
PY - 2007/6
Y1 - 2007/6
N2 - Intra-arterial infusion of acetylcholine causes classical endothelium-dependent vasodilatation that is mediated by endothelium-derived relaxing factor(s), the most prominent of which is nitric oxide. The absence of this vasodilatation, or endothelial 'dysfunction', correlates with the earliest stages of atherosclerosis and might be used to identify individuals who could benefit from aggressive intervention strategies and to assess treatment efficacy. Sex steroid hormones (estrogen and testosterone) increase the production and release of endothelium-derived nitric oxide both in men and in women. Therefore, endogenous hormonal status could present a confounding factor in the assessment of endothelial function.
AB - Intra-arterial infusion of acetylcholine causes classical endothelium-dependent vasodilatation that is mediated by endothelium-derived relaxing factor(s), the most prominent of which is nitric oxide. The absence of this vasodilatation, or endothelial 'dysfunction', correlates with the earliest stages of atherosclerosis and might be used to identify individuals who could benefit from aggressive intervention strategies and to assess treatment efficacy. Sex steroid hormones (estrogen and testosterone) increase the production and release of endothelium-derived nitric oxide both in men and in women. Therefore, endogenous hormonal status could present a confounding factor in the assessment of endothelial function.
UR - http://www.scopus.com/inward/record.url?scp=34249297914&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249297914&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2007.04.004
DO - 10.1016/j.tips.2007.04.004
M3 - Review article
C2 - 17466385
AN - SCOPUS:34249297914
SN - 0165-6147
VL - 28
SP - 263
EP - 270
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 6
ER -