Sex steroids and endothelial function: translating basic science to clinical practice

Virginia M. Miller, Sharon L. Mulvagh

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations

Abstract

Intra-arterial infusion of acetylcholine causes classical endothelium-dependent vasodilatation that is mediated by endothelium-derived relaxing factor(s), the most prominent of which is nitric oxide. The absence of this vasodilatation, or endothelial 'dysfunction', correlates with the earliest stages of atherosclerosis and might be used to identify individuals who could benefit from aggressive intervention strategies and to assess treatment efficacy. Sex steroid hormones (estrogen and testosterone) increase the production and release of endothelium-derived nitric oxide both in men and in women. Therefore, endogenous hormonal status could present a confounding factor in the assessment of endothelial function.

Original languageEnglish (US)
Pages (from-to)263-270
Number of pages8
JournalTrends in Pharmacological Sciences
Volume28
Issue number6
DOIs
StatePublished - Jun 1 2007

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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