Sex steroid signaling in the airway

Y.s. Prakash, Venkatachalem Sathish, Elizabeth A. Townsend

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The influence of sex hormones (estrogen, progesterone, testosterone) in the biology and pathophysiology of various organ systems is being increasingly recognized. While sex steroid effects, especially estrogens, on the cardiovascular system have been well studied, clinical and emerging bench research evidence exists for the role of sex hormones in airway and lung physiology and in diseases such as asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. In this chapter, we briefly define what sex differences exist in airway or lung structure and function under normal conditions, the potential role of sex steroids at different time points in life and in specific disease states, setting the stage to explore whether and how sex hormone signaling mechanisms may be contributory. We focus on the mechanisms by which estrogens, progresterone, and testosterone influence airway smooth muscle and epithelium in regulating airway tone and the potential contribution of these hormones in airway remodeling.

Original languageEnglish (US)
Title of host publicationCalcium Signaling In Airway Smooth Muscle Cells
PublisherSpringer International Publishing
Pages321-332
Number of pages12
Volume9783319013121
ISBN (Print)9783319013121, 3319013114, 9783319013114
DOIs
StatePublished - Nov 1 2013

Keywords

  • Asthma
  • Estrogen
  • Female
  • Gender
  • Lung disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Prakash, Y. S., Sathish, V., & Townsend, E. A. (2013). Sex steroid signaling in the airway. In Calcium Signaling In Airway Smooth Muscle Cells (Vol. 9783319013121, pp. 321-332). Springer International Publishing. https://doi.org/10.1007/978-3-319-01312-1_17