Sex steroid signaling in the airway

Y.s. Prakash, Venkatachalem Sathish, Elizabeth A. Townsend

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The influence of sex hormones (estrogen, progesterone, testosterone) in the biology and pathophysiology of various organ systems is being increasingly recognized. While sex steroid effects, especially estrogens, on the cardiovascular system have been well studied, clinical and emerging bench research evidence exists for the role of sex hormones in airway and lung physiology and in diseases such as asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. In this chapter, we briefly define what sex differences exist in airway or lung structure and function under normal conditions, the potential role of sex steroids at different time points in life and in specific disease states, setting the stage to explore whether and how sex hormone signaling mechanisms may be contributory. We focus on the mechanisms by which estrogens, progresterone, and testosterone influence airway smooth muscle and epithelium in regulating airway tone and the potential contribution of these hormones in airway remodeling.

Original languageEnglish (US)
Title of host publicationCalcium Signaling In Airway Smooth Muscle Cells
PublisherSpringer International Publishing
Pages321-332
Number of pages12
Volume9783319013121
ISBN (Print)9783319013121, 3319013114, 9783319013114
DOIs
StatePublished - Nov 1 2013

Fingerprint

Gonadal Steroid Hormones
Estrogens
Steroids
Testosterone
Airway Remodeling
Lung
Pulmonary Fibrosis
Cardiovascular System
Sex Characteristics
Chronic Obstructive Pulmonary Disease
Progesterone
Smooth Muscle
Asthma
Epithelium
Cardiovascular system
Pulmonary diseases
Hormones
Physiology
Muscle
Research

Keywords

  • Asthma
  • Estrogen
  • Female
  • Gender
  • Lung disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Prakash, Y. S., Sathish, V., & Townsend, E. A. (2013). Sex steroid signaling in the airway. In Calcium Signaling In Airway Smooth Muscle Cells (Vol. 9783319013121, pp. 321-332). Springer International Publishing. https://doi.org/10.1007/978-3-319-01312-1_17

Sex steroid signaling in the airway. / Prakash, Y.s.; Sathish, Venkatachalem; Townsend, Elizabeth A.

Calcium Signaling In Airway Smooth Muscle Cells. Vol. 9783319013121 Springer International Publishing, 2013. p. 321-332.

Research output: Chapter in Book/Report/Conference proceedingChapter

Prakash, YS, Sathish, V & Townsend, EA 2013, Sex steroid signaling in the airway. in Calcium Signaling In Airway Smooth Muscle Cells. vol. 9783319013121, Springer International Publishing, pp. 321-332. https://doi.org/10.1007/978-3-319-01312-1_17
Prakash YS, Sathish V, Townsend EA. Sex steroid signaling in the airway. In Calcium Signaling In Airway Smooth Muscle Cells. Vol. 9783319013121. Springer International Publishing. 2013. p. 321-332 https://doi.org/10.1007/978-3-319-01312-1_17
Prakash, Y.s. ; Sathish, Venkatachalem ; Townsend, Elizabeth A. / Sex steroid signaling in the airway. Calcium Signaling In Airway Smooth Muscle Cells. Vol. 9783319013121 Springer International Publishing, 2013. pp. 321-332
@inbook{7981bb45c2c941c1bf5353f822b786bb,
title = "Sex steroid signaling in the airway",
abstract = "The influence of sex hormones (estrogen, progesterone, testosterone) in the biology and pathophysiology of various organ systems is being increasingly recognized. While sex steroid effects, especially estrogens, on the cardiovascular system have been well studied, clinical and emerging bench research evidence exists for the role of sex hormones in airway and lung physiology and in diseases such as asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. In this chapter, we briefly define what sex differences exist in airway or lung structure and function under normal conditions, the potential role of sex steroids at different time points in life and in specific disease states, setting the stage to explore whether and how sex hormone signaling mechanisms may be contributory. We focus on the mechanisms by which estrogens, progresterone, and testosterone influence airway smooth muscle and epithelium in regulating airway tone and the potential contribution of these hormones in airway remodeling.",
keywords = "Asthma, Estrogen, Female, Gender, Lung disease",
author = "Y.s. Prakash and Venkatachalem Sathish and Townsend, {Elizabeth A.}",
year = "2013",
month = "11",
day = "1",
doi = "10.1007/978-3-319-01312-1_17",
language = "English (US)",
isbn = "9783319013121",
volume = "9783319013121",
pages = "321--332",
booktitle = "Calcium Signaling In Airway Smooth Muscle Cells",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Sex steroid signaling in the airway

AU - Prakash, Y.s.

AU - Sathish, Venkatachalem

AU - Townsend, Elizabeth A.

PY - 2013/11/1

Y1 - 2013/11/1

N2 - The influence of sex hormones (estrogen, progesterone, testosterone) in the biology and pathophysiology of various organ systems is being increasingly recognized. While sex steroid effects, especially estrogens, on the cardiovascular system have been well studied, clinical and emerging bench research evidence exists for the role of sex hormones in airway and lung physiology and in diseases such as asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. In this chapter, we briefly define what sex differences exist in airway or lung structure and function under normal conditions, the potential role of sex steroids at different time points in life and in specific disease states, setting the stage to explore whether and how sex hormone signaling mechanisms may be contributory. We focus on the mechanisms by which estrogens, progresterone, and testosterone influence airway smooth muscle and epithelium in regulating airway tone and the potential contribution of these hormones in airway remodeling.

AB - The influence of sex hormones (estrogen, progesterone, testosterone) in the biology and pathophysiology of various organ systems is being increasingly recognized. While sex steroid effects, especially estrogens, on the cardiovascular system have been well studied, clinical and emerging bench research evidence exists for the role of sex hormones in airway and lung physiology and in diseases such as asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. In this chapter, we briefly define what sex differences exist in airway or lung structure and function under normal conditions, the potential role of sex steroids at different time points in life and in specific disease states, setting the stage to explore whether and how sex hormone signaling mechanisms may be contributory. We focus on the mechanisms by which estrogens, progresterone, and testosterone influence airway smooth muscle and epithelium in regulating airway tone and the potential contribution of these hormones in airway remodeling.

KW - Asthma

KW - Estrogen

KW - Female

KW - Gender

KW - Lung disease

UR - http://www.scopus.com/inward/record.url?scp=84930020562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930020562&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-01312-1_17

DO - 10.1007/978-3-319-01312-1_17

M3 - Chapter

AN - SCOPUS:84930020562

SN - 9783319013121

SN - 3319013114

SN - 9783319013114

VL - 9783319013121

SP - 321

EP - 332

BT - Calcium Signaling In Airway Smooth Muscle Cells

PB - Springer International Publishing

ER -