Sex steroid receptors in skeletal differentiation and epithelial neoplasia: Is tissue-specific intervention possible?

John A. Copland, Melinda Sheffield-Moore, Nina Koldzic-Zizanovic, Sean Gentry, George Lamprou, Fotini Tzortzatou-Stathopoulou, Vassilis Zoumpourlis, Randall J. Urban, Spiros A. Vlahopoulos

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Sex steroids, through their receptors, have potent effects on the signal pathways involved in osteogenic or myogenic differentiation. However, a considerable segment of those signal pathways has a prominent role in epithelial neoplastic transformation. The capability to intervene locally has focused on specific ligands for the receptors. Nevertheless, many signals are mapped to interactions of steroid receptor motifs with heterologous regulatory proteins. Some of those proteins interact with the glucocorticoid receptor and other factors essential to cell fate. Interactions of steroid receptor domain motifs with heterologous proteins affect specific target pathways; consequently, manipulation of specified protein modules complexed with steroid receptors may be a next major step for enhancing molecular targeted therapeutics. In the future, intervention at specific sections of receptor primary sequence may prove therapeutically more efficient in targeting pathways of choice than ligand selectivity can be.

Original languageEnglish (US)
Pages (from-to)629-641
Number of pages13
JournalBioEssays
Volume31
Issue number6
DOIs
StatePublished - Jul 31 2009

Keywords

  • Differentiation
  • Gene expression
  • Steroid hormone
  • Steroid receptor
  • Transcription factor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Copland, J. A., Sheffield-Moore, M., Koldzic-Zizanovic, N., Gentry, S., Lamprou, G., Tzortzatou-Stathopoulou, F., Zoumpourlis, V., Urban, R. J., & Vlahopoulos, S. A. (2009). Sex steroid receptors in skeletal differentiation and epithelial neoplasia: Is tissue-specific intervention possible? BioEssays, 31(6), 629-641. https://doi.org/10.1002/bies.200800138