TY - JOUR
T1 - Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21
AU - Ostrom, Quinn T.
AU - Kinnersley, Ben
AU - Wrensch, Margaret R.
AU - Eckel-Passow, Jeanette E.
AU - Armstrong, Georgina
AU - Rice, Terri
AU - Chen, Yanwen
AU - Wiencke, John K.
AU - McCoy, Lucie S.
AU - Hansen, Helen M.
AU - Amos, Christopher I.
AU - Bernstein, Jonine L.
AU - Claus, Elizabeth B.
AU - Il'yasova, Dora
AU - Johansen, Christoffer
AU - Lachance, Daniel H.
AU - Lai, Rose K.
AU - Merrell, Ryan T.
AU - Olson, Sara H.
AU - Sadetzki, Siegal
AU - Schildkraut, Joellen M.
AU - Shete, Sanjay
AU - Rubin, Joshua B.
AU - Lathia, Justin D.
AU - Berens, Michael E.
AU - Andersson, Ulrika
AU - Rajaraman, Preetha
AU - Chanock, Stephen J.
AU - Linet, Martha S.
AU - Wang, Zhaoming
AU - Yeager, Meredith
AU - Beane Freeman, Laura E.
AU - Koutros, Stella
AU - Albanes, Demetrius
AU - Visvanathan, Kala
AU - Stevens, Victoria L.
AU - Henriksson, Roger
AU - Michaud, Dominique S.
AU - Feychting, Maria
AU - Ahlbom, Anders
AU - Giles, Graham G.
AU - Milne, Roger
AU - McKean-Cowdin, Roberta
AU - Le Marchand, Loic
AU - Stampfer, Meir
AU - Ruder, Avima M.
AU - Carreon, Tania
AU - Hallmans, Göran
AU - Zeleniuch-Jacquotte, Anne
AU - Gaziano, J. Michael
AU - Sesso, Howard D.
AU - Purdue, Mark P.
AU - White, Emily
AU - Peters, Ulrike
AU - Buring, Julie
AU - Houlston, Richard S.
AU - Jenkins, Robert B.
AU - Melin, Beatrice
AU - Bondy, Melissa L.
AU - Barnholtz-Sloan, Jill S.
N1 - Funding Information:
The results of this study were previously presented at the 2016 Annual Meeting of the Society for Neuro-Oncology, and the 2017 Annual Meeting of the American Association for Cancer Research. A pre-publication version of this manuscript was previously made available on bioRxiv (https://doi.org/10.1101/229112). QTO is supported by a Research Training Grant from the Cancer Prevention and Research Institute of Texas (CPRIT; RP160097T). The GICC was supported by grants from the National Institutes of Health, Bethesda, Maryland (R01CA139020, R01CA52689, P50097257, P30CA125123, P30CA008748, C. Thompson PI). Additional support was provided by the McNair Medical Institute and the Population Sciences Biorepository at Baylor College of Medicine. In Sweden work was additionally supported by Acta Oncologica through the Royal Swedish Academy of Science (BM salary) and The Swedish Research council and Swedish Cancer foundation. We are grateful to the National clinical brain tumor group, all clinicians and research nurses throughout Sweden who identified all cases. The UCSF Adult Glioma Study was supported by the National Institutes of Health (grant numbers R01CA52689, P50CA097257, R01CA126831, and R01CA139020), the Loglio Collective, the National Brain Tumor Foundation, the Stanley D. Lewis and Virginia S. Lewis Endowed Chair in Brain Tumor Research, the Robert Magnin Newman Endowed Chair in Neuro-oncology, and by donations from families and friends of John Berardi, Helen Glaser, Elvera Olsen, Raymond E. Cooper, and William Martinusen. This project also was supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI Grant Number UL1 RR024131. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. The collection of cancer incidence data used in this study was supported by the California Department of Public Health as part of the statewide cancer reporting program mandated by California Health and Safety Code Section 103885; the National Cancer Institute’s Surveillance, Epidemiology and End Results Program under contract HHSN261201000140C awarded to the Cancer Prevention Institute of California, contract HHSN261201000035C awarded to the University of Southern California, and contract HHSN261201000034C awarded to the Public Health Institute; and the Centers for Disease Control and Prevention’s National Program of Cancer Registries, under agreement # U58DP003862-01 awarded to the California Department of Public Health. The ideas and opinions expressed herein are those of the author(s) and endorsement by the State of California Department of Public Health, the National Cancer Institute, and the Centers for Disease Control and Prevention or their Contractors and Subcontractors is not intended nor should be inferred. Other significant contributors for the UCSF Adult Glioma Study include: M Berger, P Bracci, S Chang, J Clarke, A Molinaro, A Perry, M Pezmecki, M Prados, I Smirnov, T Tihan, K Walsh, J Wiemels, S Zheng. UK10K data generation and access was organized by the UK10K consortium and funded by the Wellcome Trust. We are grateful to all the patients and individuals for their participation and we would also like to thank the clinicians and other hospital staff, cancer registries and study staff in respective centers who contributed to the blood sample and data collection.
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex.
AB - Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex.
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U2 - 10.1038/s41598-018-24580-z
DO - 10.1038/s41598-018-24580-z
M3 - Article
C2 - 29743610
AN - SCOPUS:85046904855
SN - 2045-2322
VL - 8
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 7352
ER -