Sex-selective QT prolongation during rapid eye movement sleep

Paola A. Lanfranchi, A. S M Shamsuzzaman, Michael John Ackerman, Tomas Kara, Pavel Jurak, Robert Wolk, Virend Somers

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background - We examined the effects of the various sleep stages on RR and QT intervals in healthy subjects and tested the hypothesis that there is a differential effect of sleep stage on QT interval in women compared with men. Methods and Results - Eighteen healthy subjects (9 women, age 22 to 45 years) underwent polysomnography and simultaneous recording of ECG, blood pressure, and respiration. RR interval, RR variability, and QT values were measured in stable conditions (no abrupt changes of heart rate or blood pressure, stable breathing pattern) during inactive wakefulness during stages 2 and 3 to 4 of non-REM sleep and during REM sleep. The absolute QT interval was normalized for variations of RR (QTc). In men, RR interval and RR variability increased through all sleep stages. The QTc remained stable from wakefulness through all sleep stages. In women, however, RR interval increased only during non-REM and was virtually identical in wakefulness and in REM. RR variability remained very stable from wakefulness through all stages of sleep. Also, during REM in women, both absolute QT interval and QTc, regardless of the correction maneuver used, increased compared with wakefulness. Conclusions - The influence of sleep on RR, RR variability, and QTc is sex-dependent. We speculate that these differential sex effects on cardiac rate and repolarization may have important implications for sleep-selected cardiac arrhythmias in women.

Original languageEnglish (US)
Pages (from-to)1488-1492
Number of pages5
JournalCirculation
Volume106
Issue number12
DOIs
StatePublished - Sep 17 2002

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Wakefulness
Sleep Stages
REM Sleep
Sleep
Healthy Volunteers
Respiration
Blood Pressure
Polysomnography
Cardiac Arrhythmias
Electrocardiography
Heart Rate

Keywords

  • Nervous system
  • Sex
  • Sleep

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Lanfranchi, P. A., Shamsuzzaman, A. S. M., Ackerman, M. J., Kara, T., Jurak, P., Wolk, R., & Somers, V. (2002). Sex-selective QT prolongation during rapid eye movement sleep. Circulation, 106(12), 1488-1492. https://doi.org/10.1161/01.CIR.0000030183.10934.95

Sex-selective QT prolongation during rapid eye movement sleep. / Lanfranchi, Paola A.; Shamsuzzaman, A. S M; Ackerman, Michael John; Kara, Tomas; Jurak, Pavel; Wolk, Robert; Somers, Virend.

In: Circulation, Vol. 106, No. 12, 17.09.2002, p. 1488-1492.

Research output: Contribution to journalArticle

Lanfranchi, PA, Shamsuzzaman, ASM, Ackerman, MJ, Kara, T, Jurak, P, Wolk, R & Somers, V 2002, 'Sex-selective QT prolongation during rapid eye movement sleep', Circulation, vol. 106, no. 12, pp. 1488-1492. https://doi.org/10.1161/01.CIR.0000030183.10934.95
Lanfranchi PA, Shamsuzzaman ASM, Ackerman MJ, Kara T, Jurak P, Wolk R et al. Sex-selective QT prolongation during rapid eye movement sleep. Circulation. 2002 Sep 17;106(12):1488-1492. https://doi.org/10.1161/01.CIR.0000030183.10934.95
Lanfranchi, Paola A. ; Shamsuzzaman, A. S M ; Ackerman, Michael John ; Kara, Tomas ; Jurak, Pavel ; Wolk, Robert ; Somers, Virend. / Sex-selective QT prolongation during rapid eye movement sleep. In: Circulation. 2002 ; Vol. 106, No. 12. pp. 1488-1492.
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