TY - JOUR
T1 - Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes
AU - Action for Health in Diabetes (Look AHEAD) Research Group
AU - Espeland, Mark A.
AU - Carmichael, Owen
AU - Yasar, Sevil
AU - Hugenschmidt, Christina
AU - Hazzard, William
AU - Hayden, Kathleen M.
AU - Rapp, Stephen R.
AU - Neiberg, Rebecca
AU - Johnson, Karen C.
AU - Hoscheidt, Siobhan
AU - Mielke, Michelle M.
N1 - Funding Information:
Funding and support: The Action for Health in Diabetes is supported through the following cooperative agreements from the National Institutes of Health: DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, and DK56992. The following federal agencies have contributed support: the National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Nursing Research; National Center on Minority Health and Health Disparities; Office of Research on Women's Health; the Centers for Disease Control and Prevention; and the Department of Veterans Affairs. This research was supported in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. The Indian Health Service (I.H.S.) provided personnel, medical oversight, and use of facilities. The opinions expressed in this article are those of the authors and do not necessarily reflect the views of the I.H.S. or other funding sources.
Funding Information:
Additional support was received from the University of Pittsburgh General Clinical Research Center (GCRC) (M01RR000056), the Clinical Translational Research Center (CTRC) funded by the Clinical & Translational Science Award (UL1 RR 024153) and NIH grant (DK 046204); Frederic C. Bartter General Clinical Research Center (M01RR01346); and the Wake Forest Alzheimer's Disease Core Center (P30AG049638-01A1). C.H. received funding from K01-AG043547.
Publisher Copyright:
© 2018 the Alzheimer's Association
PY - 2018/9
Y1 - 2018/9
N2 - Introduction: Type 2 diabetes mellitus and obesity may increase risks for cognitive decline as individuals age. It is unknown whether this results in different prevalences of cognitive impairment for women and men. Methods: The Action for Health in Diabetes, a randomized controlled clinical trial of a 10-year intensive lifestyle intervention, adjudicated cases of cross-sectional cognitive impairment (mild cognitive impairment or dementia) 10–13 years after enrollment in 3802 individuals (61% women). Results: The cross-sectional prevalences of cognitive impairment were 8.3% (women) and 14.8% (men): adjusted odds ratio 0.55, 95% confidence interval [0.43, 0.71], P <.001. Demographic, clinical, and lifestyle risk factors varied between women and men but did not account for this difference, which was limited to individuals without apolipoprotein E (APOE)-ε4 alleles (interaction P =.034). Conclusions: Among overweight and obese adults with type 2 diabetes mellitus, traditional risk factors did not account for the lower prevalence of cognitive impairment observed in women compared with men.
AB - Introduction: Type 2 diabetes mellitus and obesity may increase risks for cognitive decline as individuals age. It is unknown whether this results in different prevalences of cognitive impairment for women and men. Methods: The Action for Health in Diabetes, a randomized controlled clinical trial of a 10-year intensive lifestyle intervention, adjudicated cases of cross-sectional cognitive impairment (mild cognitive impairment or dementia) 10–13 years after enrollment in 3802 individuals (61% women). Results: The cross-sectional prevalences of cognitive impairment were 8.3% (women) and 14.8% (men): adjusted odds ratio 0.55, 95% confidence interval [0.43, 0.71], P <.001. Demographic, clinical, and lifestyle risk factors varied between women and men but did not account for this difference, which was limited to individuals without apolipoprotein E (APOE)-ε4 alleles (interaction P =.034). Conclusions: Among overweight and obese adults with type 2 diabetes mellitus, traditional risk factors did not account for the lower prevalence of cognitive impairment observed in women compared with men.
KW - Cognitive impairment
KW - Obesity
KW - Risk factors
KW - Sex differences
KW - Type 2 diabetes mellitus
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U2 - 10.1016/j.jalz.2018.05.015
DO - 10.1016/j.jalz.2018.05.015
M3 - Article
C2 - 30201101
AN - SCOPUS:85052966212
SN - 1552-5260
VL - 14
SP - 1184
EP - 1192
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 9
ER -