Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes

Action for Health in Diabetes (Look AHEAD) Research Group

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Introduction: Type 2 diabetes mellitus and obesity may increase risks for cognitive decline as individuals age. It is unknown whether this results in different prevalences of cognitive impairment for women and men. Methods: The Action for Health in Diabetes, a randomized controlled clinical trial of a 10-year intensive lifestyle intervention, adjudicated cases of cross-sectional cognitive impairment (mild cognitive impairment or dementia) 10–13 years after enrollment in 3802 individuals (61% women). Results: The cross-sectional prevalences of cognitive impairment were 8.3% (women) and 14.8% (men): adjusted odds ratio 0.55, 95% confidence interval [0.43, 0.71], P <.001. Demographic, clinical, and lifestyle risk factors varied between women and men but did not account for this difference, which was limited to individuals without apolipoprotein E (APOE)-ε4 alleles (interaction P =.034). Conclusions: Among overweight and obese adults with type 2 diabetes mellitus, traditional risk factors did not account for the lower prevalence of cognitive impairment observed in women compared with men.

Original languageEnglish (US)
Pages (from-to)1184-1192
Number of pages9
JournalAlzheimer's and Dementia
Volume14
Issue number9
DOIs
StatePublished - Sep 2018

Keywords

  • Cognitive impairment
  • Obesity
  • Risk factors
  • Sex differences
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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