Sex differences in leptin modulate ventilation in heart failure

Ivan Cundrle; Virend K. Somers; Prachi Singh; Bruce D. Johnson; Christopher G. Scott; Lyle J. Olson

doi:10.1016/j.hrtlng.2017.01.008

Sex differences in leptin modulate ventilation in heart failure

Ivan Cundrle, Virend K. Somers, Prachi Singh, Bruce D. Johnson, Christopher G. Scott, Lyle J. Olson

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background Leptin modulates ventilation and circulating levels are higher in normal women than men. Objectives The aim of this study was to compare exercise ventilation and gas exchange in men and women with heart failure (HF) and their relation to circulating leptin concentration. Methods Consecutive HF patients were studied by cardiopulmonary exercise testing and assay of circulating leptin concentration. Results Fifty-seven men and 20 women were similar with respect to age, BMI, NYHA class, left ventricular ejection fraction, and peak oxygen consumption (all p > 0.05). Leptin concentration was lower (10.3 ± 10 vs. 25.3 ± 16 ng/mL; p < 0.01) and peak exercise ventilatory efficiency (V_E/VCO₂) was higher (43 ± 10 vs. 36 ± 5; p < 0.01) in men. Leptin concentration was associated with peak exercise V_E/VCO₂ (b = −0.35; F = 5.6; p = 0.02). Conclusion Men have significantly lower circulating leptin concentration and increased ventilatory drive during exercise than women with comparable HF. In men with HF, lower leptin concentration may account for an increased ventilatory drive.

Original language	English (US)
Pages (from-to)	187-191
Number of pages	5
Journal	Heart and Lung: Journal of Acute and Critical Care
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.hrtlng.2017.01.008
State	Published - May 2017

Keywords

Brain natriuretic peptide
Exercise ventilation
Leptin
Sex differences
Ventilatory efficiency

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.hrtlng.2017.01.008

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title = "Sex differences in leptin modulate ventilation in heart failure",

abstract = "Background Leptin modulates ventilation and circulating levels are higher in normal women than men. Objectives The aim of this study was to compare exercise ventilation and gas exchange in men and women with heart failure (HF) and their relation to circulating leptin concentration. Methods Consecutive HF patients were studied by cardiopulmonary exercise testing and assay of circulating leptin concentration. Results Fifty-seven men and 20 women were similar with respect to age, BMI, NYHA class, left ventricular ejection fraction, and peak oxygen consumption (all p > 0.05). Leptin concentration was lower (10.3 ± 10 vs. 25.3 ± 16 ng/mL; p < 0.01) and peak exercise ventilatory efficiency (VE/VCO2) was higher (43 ± 10 vs. 36 ± 5; p < 0.01) in men. Leptin concentration was associated with peak exercise VE/VCO2 (b = −0.35; F = 5.6; p = 0.02). Conclusion Men have significantly lower circulating leptin concentration and increased ventilatory drive during exercise than women with comparable HF. In men with HF, lower leptin concentration may account for an increased ventilatory drive.",

keywords = "Brain natriuretic peptide, Exercise ventilation, Leptin, Sex differences, Ventilatory efficiency",

author = "Ivan Cundrle and Somers, {Virend K.} and Prachi Singh and Johnson, {Bruce D.} and Scott, {Christopher G.} and Olson, {Lyle J.}",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2017",

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doi = "10.1016/j.hrtlng.2017.01.008",

language = "English (US)",

volume = "46",

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T1 - Sex differences in leptin modulate ventilation in heart failure

AU - Cundrle, Ivan

AU - Somers, Virend K.

AU - Singh, Prachi

AU - Johnson, Bruce D.

AU - Scott, Christopher G.

AU - Olson, Lyle J.

PY - 2017/5

Y1 - 2017/5

N2 - Background Leptin modulates ventilation and circulating levels are higher in normal women than men. Objectives The aim of this study was to compare exercise ventilation and gas exchange in men and women with heart failure (HF) and their relation to circulating leptin concentration. Methods Consecutive HF patients were studied by cardiopulmonary exercise testing and assay of circulating leptin concentration. Results Fifty-seven men and 20 women were similar with respect to age, BMI, NYHA class, left ventricular ejection fraction, and peak oxygen consumption (all p > 0.05). Leptin concentration was lower (10.3 ± 10 vs. 25.3 ± 16 ng/mL; p < 0.01) and peak exercise ventilatory efficiency (VE/VCO2) was higher (43 ± 10 vs. 36 ± 5; p < 0.01) in men. Leptin concentration was associated with peak exercise VE/VCO2 (b = −0.35; F = 5.6; p = 0.02). Conclusion Men have significantly lower circulating leptin concentration and increased ventilatory drive during exercise than women with comparable HF. In men with HF, lower leptin concentration may account for an increased ventilatory drive.

AB - Background Leptin modulates ventilation and circulating levels are higher in normal women than men. Objectives The aim of this study was to compare exercise ventilation and gas exchange in men and women with heart failure (HF) and their relation to circulating leptin concentration. Methods Consecutive HF patients were studied by cardiopulmonary exercise testing and assay of circulating leptin concentration. Results Fifty-seven men and 20 women were similar with respect to age, BMI, NYHA class, left ventricular ejection fraction, and peak oxygen consumption (all p > 0.05). Leptin concentration was lower (10.3 ± 10 vs. 25.3 ± 16 ng/mL; p < 0.01) and peak exercise ventilatory efficiency (VE/VCO2) was higher (43 ± 10 vs. 36 ± 5; p < 0.01) in men. Leptin concentration was associated with peak exercise VE/VCO2 (b = −0.35; F = 5.6; p = 0.02). Conclusion Men have significantly lower circulating leptin concentration and increased ventilatory drive during exercise than women with comparable HF. In men with HF, lower leptin concentration may account for an increased ventilatory drive.

KW - Brain natriuretic peptide

KW - Exercise ventilation

KW - Leptin

KW - Sex differences

KW - Ventilatory efficiency

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Sex differences in leptin modulate ventilation in heart failure

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