Sex differences in left ventricular geometry in aortic stenosis: Impact on outcome

Donna L. Milavetz, Sharonne N. Hayes, Susan A. Weston, James B. Seward, Charles J. Mullany, Véronique L. Roger

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Objective: This study of surgical aortic stenosis characterized sex differences in left ventricular (LV) geometry and outcome. Materials and methods: We examined 92 women and 82 men who underwent echocardiography before valve replacement for aortic stenosis. Results: Women had a smaller cavity size (LV end-diastolic diameter 48.2 ± 7 mm in women vs 53.6 ± 7.6 mm in men; p = 0.0001) and higher ejection fraction (59% in women vs 54% in men; p = 0.02). LV mass was greater in men than women (300.4 ± 88 g in men vs 250.6 ± 85.8g in women; p = 0.0055) but when corrected for body surface area, the difference was not significant. The prevalence of LV hypertrophy was similar in both sexes (51% in women vs 49% in men; p = 0.62). The 5-year survival was 82% in women and 79% in men (p = 0.9). Conclusion: Several descriptors of LV geometry differed between men and women. These differences were largely eliminated after normalizing for body surface area. No differences in surgical mortality or long-term outcome were noted.

Original languageEnglish (US)
Pages (from-to)1094-1099
Number of pages6
Issue number4
StatePublished - Jan 1 2000


  • Aortic valve disease
  • Outcome left ventricular geometry
  • Sex difference

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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