Sex differences in inflammation during atherosclerosis

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

Atherosclerosis is the leading cause of death in the United States and worldwide, yet more men die from atherosclerosis than women, and at a younger age. Women, on the other hand, mainly develop atherosclerosis following menopause, and particularly if they have one or more autoimmune diseases, suggesting that the immune mechanisms that increase disease in men are different from those in women. The key processes in the pathogenesis of atherosclerosis are vascular inflammation, lipid accumulation, intimal thickening and fibrosis, remodeling, and plaque rupture or erosion leading to myocardial infarction and ischemia. Evidence indicates that sex hormones alter the immune response during atherosclerosis, resulting in different disease phenotypes according to sex. Women, for example, respond to infection and damage with increased antibody and autoantibody responses, while men have elevated innate immune activation. This review describes current knowledge regarding sex differences in the inflammatory immune response during athero-sclerosis. Understanding sex differences is critical for improving individualized medicine.

Original languageEnglish (US)
Pages (from-to)49-59
Number of pages11
JournalClinical Medicine Insights: Cardiology
Volume8
Issue numberSuppl. 3
DOIs
StatePublished - Feb 2014

Keywords

  • Autoantibodies
  • Inflammasome
  • Macrophages
  • Myocardial infarct
  • Myocarditis
  • Sex hormones

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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