Sex differences in fluorouracil-induced stomatitis

Jeff A Sloan, Charles Lawrence Loprinzi, Paul J. Novotny, Scott Heitaka Okuno, Suresh Nair, Debra L. Barton

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Purpose: A meta-analysis of six North Central Cancer Treatment Group (NCCTG) trials involving patients receiving their first ever fluorouracil (5- FU)-based chemotherapy was undertaken to explore the association of sex with reports of the incidence and severity of stomatitis. Patients and Methods: Data were obtained on a total of 731 patients (402 men and 329 women). Comparisons of incidence and severity rates and average stomatitis across sex were performed using standard binomial testing and t tests, respectively. Logistic regression analysis and a weighted analysis using data summarized to study level served as evidence of cross-validation. Results: Women reported stomatitis both more often and with greater severity than did men. The incidence of any stomatitis for women was 63% versus 52% for men (P = .002). The incidence of severe or very severe stomatitis for men and women was 22% and 12%, respectively (P = .0006). On average, women reported stomatitis of roughly 0.4 points higher than men on a 0 to 4 ordinal scale (P < .00001). Comparison of results across treatment and placebo arms was carried out to validate the initial findings. Logistic regression modelling further confirmed the results conditional on the presence of a number of potentially confounding covariates. Women were also 11% more likely than men to experience leukopenia of common toxicity criteria grade ≥ 1, (70% v 59%, respectively; P < .00001) and grade 3+ (18% v 11%, respectively; P = .004). Conclusion: More women than men reported 5-FU-induced stomatitis. The precise mechanism resulting in different degrees of stomatitis across sex is not evident.

Original languageEnglish (US)
Pages (from-to)412-420
Number of pages9
JournalJournal of Clinical Oncology
Volume18
Issue number2
StatePublished - Jan 2000

Fingerprint

Stomatitis
Fluorouracil
Sex Characteristics
Incidence
Logistic Models
Leukopenia
Meta-Analysis
Placebos
Regression Analysis
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sex differences in fluorouracil-induced stomatitis. / Sloan, Jeff A; Loprinzi, Charles Lawrence; Novotny, Paul J.; Okuno, Scott Heitaka; Nair, Suresh; Barton, Debra L.

In: Journal of Clinical Oncology, Vol. 18, No. 2, 01.2000, p. 412-420.

Research output: Contribution to journalArticle

Sloan, JA, Loprinzi, CL, Novotny, PJ, Okuno, SH, Nair, S & Barton, DL 2000, 'Sex differences in fluorouracil-induced stomatitis', Journal of Clinical Oncology, vol. 18, no. 2, pp. 412-420.
Sloan, Jeff A ; Loprinzi, Charles Lawrence ; Novotny, Paul J. ; Okuno, Scott Heitaka ; Nair, Suresh ; Barton, Debra L. / Sex differences in fluorouracil-induced stomatitis. In: Journal of Clinical Oncology. 2000 ; Vol. 18, No. 2. pp. 412-420.
@article{69c941eb51f54784b1daeb56216d3496,
title = "Sex differences in fluorouracil-induced stomatitis",
abstract = "Purpose: A meta-analysis of six North Central Cancer Treatment Group (NCCTG) trials involving patients receiving their first ever fluorouracil (5- FU)-based chemotherapy was undertaken to explore the association of sex with reports of the incidence and severity of stomatitis. Patients and Methods: Data were obtained on a total of 731 patients (402 men and 329 women). Comparisons of incidence and severity rates and average stomatitis across sex were performed using standard binomial testing and t tests, respectively. Logistic regression analysis and a weighted analysis using data summarized to study level served as evidence of cross-validation. Results: Women reported stomatitis both more often and with greater severity than did men. The incidence of any stomatitis for women was 63{\%} versus 52{\%} for men (P = .002). The incidence of severe or very severe stomatitis for men and women was 22{\%} and 12{\%}, respectively (P = .0006). On average, women reported stomatitis of roughly 0.4 points higher than men on a 0 to 4 ordinal scale (P < .00001). Comparison of results across treatment and placebo arms was carried out to validate the initial findings. Logistic regression modelling further confirmed the results conditional on the presence of a number of potentially confounding covariates. Women were also 11{\%} more likely than men to experience leukopenia of common toxicity criteria grade ≥ 1, (70{\%} v 59{\%}, respectively; P < .00001) and grade 3+ (18{\%} v 11{\%}, respectively; P = .004). Conclusion: More women than men reported 5-FU-induced stomatitis. The precise mechanism resulting in different degrees of stomatitis across sex is not evident.",
author = "Sloan, {Jeff A} and Loprinzi, {Charles Lawrence} and Novotny, {Paul J.} and Okuno, {Scott Heitaka} and Suresh Nair and Barton, {Debra L.}",
year = "2000",
month = "1",
language = "English (US)",
volume = "18",
pages = "412--420",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "2",

}

TY - JOUR

T1 - Sex differences in fluorouracil-induced stomatitis

AU - Sloan, Jeff A

AU - Loprinzi, Charles Lawrence

AU - Novotny, Paul J.

AU - Okuno, Scott Heitaka

AU - Nair, Suresh

AU - Barton, Debra L.

PY - 2000/1

Y1 - 2000/1

N2 - Purpose: A meta-analysis of six North Central Cancer Treatment Group (NCCTG) trials involving patients receiving their first ever fluorouracil (5- FU)-based chemotherapy was undertaken to explore the association of sex with reports of the incidence and severity of stomatitis. Patients and Methods: Data were obtained on a total of 731 patients (402 men and 329 women). Comparisons of incidence and severity rates and average stomatitis across sex were performed using standard binomial testing and t tests, respectively. Logistic regression analysis and a weighted analysis using data summarized to study level served as evidence of cross-validation. Results: Women reported stomatitis both more often and with greater severity than did men. The incidence of any stomatitis for women was 63% versus 52% for men (P = .002). The incidence of severe or very severe stomatitis for men and women was 22% and 12%, respectively (P = .0006). On average, women reported stomatitis of roughly 0.4 points higher than men on a 0 to 4 ordinal scale (P < .00001). Comparison of results across treatment and placebo arms was carried out to validate the initial findings. Logistic regression modelling further confirmed the results conditional on the presence of a number of potentially confounding covariates. Women were also 11% more likely than men to experience leukopenia of common toxicity criteria grade ≥ 1, (70% v 59%, respectively; P < .00001) and grade 3+ (18% v 11%, respectively; P = .004). Conclusion: More women than men reported 5-FU-induced stomatitis. The precise mechanism resulting in different degrees of stomatitis across sex is not evident.

AB - Purpose: A meta-analysis of six North Central Cancer Treatment Group (NCCTG) trials involving patients receiving their first ever fluorouracil (5- FU)-based chemotherapy was undertaken to explore the association of sex with reports of the incidence and severity of stomatitis. Patients and Methods: Data were obtained on a total of 731 patients (402 men and 329 women). Comparisons of incidence and severity rates and average stomatitis across sex were performed using standard binomial testing and t tests, respectively. Logistic regression analysis and a weighted analysis using data summarized to study level served as evidence of cross-validation. Results: Women reported stomatitis both more often and with greater severity than did men. The incidence of any stomatitis for women was 63% versus 52% for men (P = .002). The incidence of severe or very severe stomatitis for men and women was 22% and 12%, respectively (P = .0006). On average, women reported stomatitis of roughly 0.4 points higher than men on a 0 to 4 ordinal scale (P < .00001). Comparison of results across treatment and placebo arms was carried out to validate the initial findings. Logistic regression modelling further confirmed the results conditional on the presence of a number of potentially confounding covariates. Women were also 11% more likely than men to experience leukopenia of common toxicity criteria grade ≥ 1, (70% v 59%, respectively; P < .00001) and grade 3+ (18% v 11%, respectively; P = .004). Conclusion: More women than men reported 5-FU-induced stomatitis. The precise mechanism resulting in different degrees of stomatitis across sex is not evident.

UR - http://www.scopus.com/inward/record.url?scp=0033955224&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033955224&partnerID=8YFLogxK

M3 - Article

C2 - 10637257

AN - SCOPUS:0033955224

VL - 18

SP - 412

EP - 420

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 2

ER -